https://scholars.lib.ntu.edu.tw/handle/123456789/585960
標題: | Prior beta-blocker treatment improves outcomes in out-of-hospital cardiac arrest patients with non-shockable rhythms | 作者: | HUI-CHUN HUANG Yu, Ping-Hsun MIN-SHAN TSAI KUO-LIONG CHIEN WEN-JONE CHEN CHIEN-HUA HUANG |
公開日期: | 19-八月-2021 | 卷: | 11 | 期: | 1 | 來源出版物: | Scientific reports | 摘要: | The prognosis of out of cardiac arrest is poor and most cardiac arrest patients suffered from the non-shockable rhythm especially in patients without pre-existing cardiovascular diseases and medication prescription. Beta-blocker (ß-blocker) therapy has been shown to improve outcomes in cardiovascular diseases such as heart failure, ischemia related cardiac, and brain injuries. Therefore, we investigated whether prior ß-blockers use was associated with reduced mortality in patients with cardiac arrest and non-shockable rhythm. We conducted a population-based retrospective cohort study using multivariate propensity score-based regression to control for differences among patients with cardiac arrest. A total of 104,568 adult patients suffering a non-traumatic and non-shockable rhythm cardiac arrest between 2005 and 2011 were identified. ß-blocker prescription at least 30 days prior to the cardiac arrest event was defines as the ß-blockers group. We chose 12.5 mg carvedilol as the cut-off value and defined greater or equal to carvedilol 12.5 mg per day and its equivalent dose as high-dose group. After multivariate propensity score-based logistic regression analysis, patients with prior ß-blockers use were associated with better 1-year survival [adjusted odds ratio (OR), 1.15, 95% confidence interval (CI) 1.01-1.30; P = 0.031]. Compared to non-ß-blocker use group and prior low-dose ß-blockers use group, prior high-dose ß-blockers use group was associated with higher mechanical ventilator wean success rate (adjusted OR 1.19, 95% CI 1.01-1.41, P = 0.042). In conclusion, prior high dose ß-blockers use was associated with a better 1-year survival and higher weaning rate in patients with non-shockable cardiac arrest. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/585960 | ISSN: | 2045-2322 | DOI: | 10.1038/s41598-021-96070-8 | SDG/關鍵字: | beta adrenergic receptor blocking agent; aged; cardioversion; female; human; male; multivariate analysis; out of hospital cardiac arrest; propensity score; statistical model; survival analysis; treatment outcome; Adrenergic beta-Antagonists; Aged; Electric Countershock; Female; Humans; Logistic Models; Male; Multivariate Analysis; Out-of-Hospital Cardiac Arrest; Propensity Score; Survival Analysis; Treatment Outcome |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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