https://scholars.lib.ntu.edu.tw/handle/123456789/586528
標題: | Nanoparticle composite TPNT1 is effective against SARS-CoV-2 and influenza viruses | 作者: | SUI-YUAN CHANG Huang, Kuo-Yen TAI-LING CHAO Kao, Han-Chieh Pang, Yu-Hao Lu, Lin Chiu, Chun-Lun Huang, Hsin-Chang Cheng, Ting-Jen Rachel JIM-MIN FANG PAN-CHYR YANG |
公開日期: | 2021 | 卷: | 11 | 期: | 1 | 來源出版物: | Scientific reports | 摘要: | A metal nanoparticle composite, namely TPNT1, which contains Au-NP (1 ppm), Ag-NP (5 ppm), ZnO-NP (60 ppm) and ClO2 (42.5 ppm) in aqueous solution was prepared and characterized by spectroscopy, transmission electron microscopy, dynamic light scattering analysis and potentiometric titration. Based on the in vitro cell-based assay, TPNT1 inhibited six major clades of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with effective concentration within the range to be used as food additives. TPNT1 was shown to block viral entry by inhibiting the binding of SARS-CoV-2 spike proteins to the angiotensin-converting enzyme 2 (ACE2) receptor and to interfere with the syncytium formation. In addition, TPNT1 also effectively reduced the cytopathic effects induced by human (H1N1) and avian (H5N1) influenza viruses, including the wild-type and oseltamivir-resistant virus isolates. Together with previously demonstrated efficacy as antimicrobials, TPNT1 can block viral entry and inhibit or prevent viral infection to provide prophylactic effects against both SARS-CoV-2 and opportunistic infections. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/586528 | ISSN: | 2045-2322 | DOI: | 10.1038/s41598-021-87254-3 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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