https://scholars.lib.ntu.edu.tw/handle/123456789/587985
DC 欄位 | 值 | 語言 |
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dc.contributor.author | Charidimou A. | en_US |
dc.contributor.author | Farid K. | en_US |
dc.contributor.author | Tsai H.-H. | en_US |
dc.contributor.author | LI-KAI TSAI | en_US |
dc.contributor.author | RUOH-FANG YEN | en_US |
dc.contributor.author | Baron J.-C. | en_US |
dc.date.accessioned | 2021-11-26T05:56:33Z | - |
dc.date.available | 2021-11-26T05:56:33Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 223050 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85045035814&doi=10.1136%2fjnnp-2017-316851&partnerID=40&md5=2a38f0a1cb06b5b99d66ce5a77bb8630 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/587985 | - |
dc.description.abstract | Introduction We performed a meta-analysis to synthesise current evidence on amyloid-positron emission tomography (PET) burden and presumed preferential occipital distribution in sporadic cerebral amyloid angiopathy (CAA). Methods In a PubMed systematic search, we identified case-control studies with extractable data on global and occipital-to-global amyloid-PET uptake in symptomatic patients with CAA (per Boston criteria) versus control groups (healthy participants or patients with non-CAA deep intracerebral haemorrhage) and patients with Alzheimer's disease. To circumvent PET studies' methodological variation, we generated and used € fold change', that is, ratio of mean amyloid uptake (global and occipital-to-global) of CAA relative to comparison groups. Amyloid-PET uptake biomarker performance was then quantified by random-effects meta-analysis on the ratios of the means. A ratio >1 indicates that amyloid-PET uptake (global or occipital/global) is higher in CAA than comparison groups, and a ratio <1 indicates the reverse. Results Seven studies, including 106 patients with CAA (>90% with probable CAA) and 138 controls (96 healthy elderly, 42 deep intracerebral haemorrhage controls) and 72 patients with Alzheimer's disease, were included. Global amyloid-PET ratio between patients with CAA and controls was above 1, with an average effect size of 1.18 (95% CI 1.08 to 1.28; p<0.0001). Occipital-to-global amyloid-PET uptake ratio did not differ between patients with CAA versus patients with deep intracerebral haemorrhage or healthy controls. By contrast, occipital-to-global amyloid-PET uptake ratio was above 1 in patients with CAA versus those with Alzheimer's disease, with an average ratio of 1.10 (95% CI 1.03 to 1.19; p=0.009) and high statistical heterogeneity. Conclusions Our analysis provides exploratory actionable data on the overall effect sizes and strength of amyloid-PET burden and distribution in patients with CAA, useful for future larger studies. ? Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. | - |
dc.relation.ispartof | Journal of Neurology, Neurosurgery and Psychiatry | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | amyloid; 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; amyloid beta protein; aniline derivative; ethylene glycol derivative; florbetapir; thiazole derivative; Alzheimer disease; Article; brain hemorrhage; contrast; disease burden; evidence based medicine; human; positron emission tomography; priority journal; protein localization; protein transport; systematic review; vascular amyloidosis; diagnostic imaging; meta analysis; metabolism; positron emission tomography; vascular amyloidosis; Amyloid beta-Peptides; Aniline Compounds; Cerebral Amyloid Angiopathy; Ethylene Glycols; Humans; Positron-Emission Tomography; Thiazoles | - |
dc.title | Amyloid-PET burden and regional distribution in cerebral amyloid angiopathy: A systematic review and meta-analysis of biomarker performance | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1136/jnnp-2017-316851 | - |
dc.identifier.pmid | 29070646 | - |
dc.identifier.scopus | 2-s2.0-85045035814 | - |
dc.relation.pages | 410-417 | - |
dc.relation.journalvolume | 89 | - |
dc.relation.journalissue | 4 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | no fulltext | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Neurology-NTUH | - |
crisitem.author.dept | Neurology | - |
crisitem.author.dept | The Clinical Center for Neuroscience and Behavior | - |
crisitem.author.dept | Radiology | - |
crisitem.author.dept | Nuclear Medicine-NTUH | - |
crisitem.author.orcid | 0000-0001-8420-6951 | - |
crisitem.author.orcid | 0000-0003-1648-6482 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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