https://scholars.lib.ntu.edu.tw/handle/123456789/588053
標題: | Neurological manifestations in severe acute respiratory syndrome | 作者: | LI-KAI TSAI SUNG-TSANG HSIEH Chang Y.-C. |
公開日期: | 2005 | 卷: | 14 | 期: | 3 | 起(迄)頁: | 113-119 | 來源出版物: | Acta Neurologica Taiwanica | 摘要: | During the worldwide outbreak of severe acute respiratory syndrome (SARS) in 2002-2003, there were 664 probable SARS patients reported in Taiwan. SARS patients usually present with symptoms related to the respiratory system while neurological manifestations have rarely been described. There were three patients who developed axonopathic polyneuropathy 3-4 weeks after onset of SARS; their clinical condition and electrophysiological studies revealed obvious improvement at follow-up. Two SARS patients have experienced myopathy and three other patients developed rhabdomyolysis. These neuromuscular disorders in SARS patients were considered as critical illness neuropathy and myopathy, but the possibility of direct attack by SARS coronavirus on the nerve and muscle could not be excluded. Large artery ischemic stroke were described in five SARS patients with poor prognosis. Multiple factors contributed to this vascular insult included hypercoagulabe status related to both SARS coronavirus and the usage of intravenous immunoglobulin, septic and cardiogenic shock, and possible vasculitis. The relationship between SARS and above neurological problems still needs further clarification. Pathological and microbiological studies are mandatory to delineate this issue. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-26244435815&partnerID=40&md5=f40d6365abea9360e17eb8829bf2fa4a https://scholars.lib.ntu.edu.tw/handle/123456789/588053 |
ISSN: | 10196099 | SDG/關鍵字: | immunoglobulin; methylprednisolone; brain infarction; cerebrovascular accident; critical illness; disease association; drug megadose; electrophysiology; follow up; human; hypercoagulability; microbial activity; myopathy; polyneuropathy; prognosis; pulsatile drug release; review; rhabdomyolysis; SARS coronavirus; severe acute respiratory syndrome; Cerebral Infarction; Humans; Immunoglobulins, Intravenous; Polyneuropathies; Rhabdomyolysis; Severe Acute Respiratory Syndrome |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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