https://scholars.lib.ntu.edu.tw/handle/123456789/588532
標題: | KLOTHO methylation is linked to uremic toxins and chronic kidney disease | 作者: | Young G.-H. VIN-CENT WU |
公開日期: | 2012 | 出版社: | Nature Publishing Group | 卷: | 81 | 期: | 7 | 起(迄)頁: | 611-612 | 來源出版物: | Kidney International | 摘要: | Epigenetic regulation plays a major role in uremic toxin-induced chronic kidney disease (CKD) progression. The KLOTHO protein is a key modulator of homeostasis in renal function. Uremic toxin accumulation can induce DNA methyltransferase (DNMT) protein expression, which is involved in the silencing of KLOTHO through hypermethylation. Treatment with DNMT inhibitors can induce a hypermethylated status of KLOTHO and suppress mRNA and protein expression. Epigenetic targeting of specific genes may become an effective strategy to prevent progression of uremia-related CKD. ? 2012 International Society of Nephrology. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84858305531&doi=10.1038%2fki.2011.461&partnerID=40&md5=f5351f446e80efae73beb31951921417 https://scholars.lib.ntu.edu.tw/handle/123456789/588532 |
ISSN: | 0085-2538 | DOI: | 10.1038/ki.2011.461 | SDG/關鍵字: | DNA methyltransferase; fibroblast growth factor 23; indican; Klotho protein; messenger RNA; reactive oxygen metabolite; somatomedin C; uremic toxin; bioaccumulation; chronic kidney disease; disease association; DNA methylation; DNA modification; down regulation; epigenetics; gene overexpression; gene silencing; genetic association; human; inflammation; kidney dysfunction; nonhuman; oxidative stress; pathogenesis; priority journal; protein expression; protein function; protein methylation; review; signal transduction; uremia |
顯示於: | 醫學系 |
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