https://scholars.lib.ntu.edu.tw/handle/123456789/588634
標題: | Transforming growth factor-β1 decreases erythropoietin production through repressing hypoxia-inducible factor 2α in erythropoietin-producing cells | 作者: | Shih, Hong-Mou SZU-YU PAN Wu, Chih-Jen Chou, Yu-Hsiang Chen, Chun-Yuan FAN-CHI CHANG YI-TING CHEN WEN-CHIH CHIANG HSING-CHEN TSAI YUNG-MING CHEN SHUEI-LIONG LIN |
關鍵字: | Erythropoietin; Hypoxia-inducible factor 2α; Pericyte; Transforming growth factor-β1 | 公開日期: | 2-十一月-2021 | 卷: | 28 | 期: | 1 | 來源出版物: | Journal of biomedical science | 摘要: | Renal erythropoietin (EPO)-producing (REP) cells produce EPO through hypoxia-inducible factor (HIF) 2α-activated gene transcription. Insufficient EPO production leads to anemia in patients with chronic kidney disease. Although recombinant EPO is effective to improve anemia, no reliable REP cell lines limit further progress of research and development of novel treatment. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/588634 | ISSN: | 10217770 | DOI: | 10.1186/s12929-021-00770-2 |
顯示於: | 醫學系 |
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