https://scholars.lib.ntu.edu.tw/handle/123456789/588634| Title: | Transforming growth factor-β1 decreases erythropoietin production through repressing hypoxia-inducible factor 2α in erythropoietin-producing cells | Authors: | Shih, Hong-Mou Pan, Szu-Yu Wu, Chih-Jen Chou, Yu-Hsiang Chen, Chun-Yuan Chang, Fan-Chi Chen, Yi-Ting Chiang, Wen-Chih Tsai, Hsing-Chen Chen, Yung-Ming Lin, Shuei-Liong |
Keywords: | Erythropoietin; Hypoxia-inducible factor 2α; Pericyte; Transforming growth factor-β1 | Issue Date: | 2-Nov-2021 | Journal Volume: | 28 | Journal Issue: | 1 | Source: | Journal of biomedical science | Abstract: | Renal erythropoietin (EPO)-producing (REP) cells produce EPO through hypoxia-inducible factor (HIF) 2α-activated gene transcription. Insufficient EPO production leads to anemia in patients with chronic kidney disease. Although recombinant EPO is effective to improve anemia, no reliable REP cell lines limit further progress of research and development of novel treatment. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/588634 | ISSN: | 10217770 | DOI: | 10.1186/s12929-021-00770-2 |
| Appears in Collections: | 醫學系 |
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