https://scholars.lib.ntu.edu.tw/handle/123456789/588821
標題: | Seroprevalence of hepatitis B virus among adults at high risk for HIV transmission two decades after implementation of nationwide hepatitis B virus vaccination program in Taiwan | 作者: | HSIN-YUN SUN Cheng C.-Y. Lee N.-Y. Yang C.-J. Liang S.-H. Tsai M.-S. Ko W.-C. Liu W.-C. Wu P.-Y. Wu C.-H. Lin H.-H. CHIEN-CHING HUNG |
公開日期: | 2014 | 出版社: | Public Library of Science | 卷: | 9 | 期: | 2 | 起(迄)頁: | e90194 | 來源出版物: | PLoS ONE | 摘要: | Background: Seroprevalence of hepatitis B virus (HBV) after implementation of universal neonatal HBV vaccination and catch-up vaccination programs remains rarely investigated among the adults who were born in the vaccination era (in or after 1986) and engaged in high-risk sexual behaviors. Materials and Methods: Between 2006 and 2012, we determined HBV surface antigen ([HBsAg), anti-HBs, and HBV core antibody (anti-HBc), hepatitis C virus antibody (anti-HCV) and rapid plasma reagin titers among HIV-infected men who have sex with men (MSM) born during 1984-1985 (Group I: 244 persons) and those born in or after 1986 (Group II: 523), and HIV-uninfected MSM (Group III: 377) and heterosexuals (Group IV: 217) born in or after 1986. Prevalence and incidence of HBV infection were estimated and multivariate analysis was performed to identify factors associated with HBsAg positivity. Results: Compared with Group I, Groups II-IV had a significantly lower prevalence of HBsAg positivity (7.8% vs 3.7%, 2.4%, and 3.2%, respectively); and the prevalence of anti-HBc positivity was also lower for Groups III and IV (30.3% vs. 19.6%, and 18.0%, respectively), but no difference was observed between Groups I and II (30.3% vs. 26.3%). In multivariate analysis, HBsAg positivity was significantly associated with syphilis (adjusted odds ratio, 2.990; 95% confidence interval, 1.502-5.953) and anti-HCV positivity (adjusted odds ratio, 3.402; 95% confidence interval, 1.091-10.614). In subjects of Group II with allnegative HBV markers at baseline, the incidence rate of HBsAg seroconversion was 0.486 episodes per 100 person-years; and for those who received combination antiretroviral therapy containing lamivudine and/or tenofovir, none developed HBsAg seroconversion during the follow-up. Conclusions: Among the adults who were born in or after 1986 and engaged in high-risk sexual behaviors in Taiwan, neonatal HBV vaccination and catch-up vaccination programs conferred long-term protection against HBsAg seroconversion and HBsAg positivity was associated with syphilis and anti-HCV positivity. ? 2014 Sun et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84896280193&doi=10.1371%2fjournal.pone.0090194&partnerID=40&md5=8f82fda61ff176c9c8d972b26fff1f25 https://scholars.lib.ntu.edu.tw/handle/123456789/588821 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0090194 | SDG/關鍵字: | hepatitis B core antibody; hepatitis B surface antigen; hepatitis B vaccine; hepatitis C antibody; lamivudine; reaginic antibody; tenofovir disoproxil; adult; article; controlled study; hepatitis B; Hepatitis B virus; heterosexuality; high risk population; human; Human immunodeficiency virus infection; major clinical study; male; men who have sex with men; morbidity; multivariate analysis; seroconversion; seroprevalence; sexual behavior; syphilis; Taiwan; vaccination; virus transmission; Adult; Antibodies, Viral; Chronic Disease; Female; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; HIV Infections; Humans; Infant, Newborn; Male; Risk; Seroepidemiologic Studies; Syphilis; Taiwan; Vaccination |
顯示於: | 醫學系 |
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