https://scholars.lib.ntu.edu.tw/handle/123456789/588899
標題: | Streptococcus pneumoniae colonization among patients with human immunodeficiency virus-1 who had received 23-valent polysaccharide pneumococcal vaccine | 作者: | Lo Y.-C. Lauderdale T.-L. SUI-YUAN CHANG Hsiao C.-F. CHIEN-CHING HUNG SHAN-CHWEN CHANG |
公開日期: | 2009 | 卷: | 42 | 期: | 3 | 起(迄)頁: | 234-242 | 來源出版物: | Journal of Microbiology, Immunology and Infection | 摘要: | Background and purpose: To evaluate the impact of 23-valent polysaccharide pneumococcal vaccine on Streptococcus pneumoniae colonization in the upper airway of patients with human immunodeficiency virus (HIV)-1 in Taiwan. Methods: 302 HIV-infected patients aged 15 years or older underwent swab cultures of the posterior pharynx and tonsils for S. pneumoniae between June 1, 2000 and June 30, 2002. 198 patients (65.6%) had received 23-valent polysaccharide pneumococcal vaccine with a median interval of 420 days (range, 27-634 days) before cultures were performed. Clinical characteristics and laboratory findings were analyzed to determine the factors associated with S. pneumoniae colonization in the upper airway. Results: Twenty patients (6.6%) had colonization with S. pneumoniae: 15 of 198 patients (7.6%) who had received 23-valent polysaccharide pneumococcal vaccine and 5 of 104 patients (4.8%) who had not received the vaccine (p = 0.37). According to the multivariate analysis, smoking was the only factor that was statistically significantly associated with S. pneumoniae colonization (adjusted odds ratio, 4.03; 95% confidence interval, 1.04-15.64; p = 0.04); pneumococcal vaccination was not statistically significantly associated with S. pneumoniae colonization. Conclusions: Among HIV-infected patients, smoking was the only factor significantly associated with a higher prevalence of upper airway colonization by S. pneumoniae. As previous receipt of 23-valent polysaccharide pneumococcal vaccine was not associated with a lower prevalence of S. pneumoniae colonization, a better vaccination strategy, in addition to smoking cessation, may be needed to reduce S. pneumoniae colonization in HIV-infected adults. ? 2009 Journal of Microbiology, Immunology and Infection. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-70349932535&partnerID=40&md5=9da518d390dbb87a4c4ce011b0398e6e https://scholars.lib.ntu.edu.tw/handle/123456789/588899 |
ISSN: | 1684-1182 | SDG/關鍵字: | anti human immunodeficiency virus agent; cephalosporin derivative; clarithromycin; cotrimoxazole; macrolide; penicillin derivative; penicillin G; Pneumococcus vaccine; quinoline derived antiinfective agent; adolescent; adult; article; bacterial colonization; bacterium culture; CD4 lymphocyte count; controlled study; female; highly active antiretroviral therapy; human; Human immunodeficiency virus 1; Human immunodeficiency virus 1 infection; major clinical study; male; pneumococcal infection; smoking; Streptococcus pneumoniae; throat culture; tonsil; upper respiratory tract infection; vaccination; Adult; Aged; Carrier State; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Multivariate Analysis; Pneumococcal Infections; Pneumococcal Vaccines; Risk Factors; Smoking; Streptococcus pneumoniae; Young Adult |
顯示於: | 醫學系 |
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