https://scholars.lib.ntu.edu.tw/handle/123456789/589030
Title: | Molecular evidence for strain dissemination of Penicillium marneffei: An emerging pathogen in Taiwan | Authors: | PO-REN HSUEH LEE-JENE TENG CHIEN-CHING HUNG Hsu J.-H. PAN-CHYR YANG Ho S.-W. KWEN-TAY LUH |
Issue Date: | 2000 | Journal Volume: | 181 | Journal Issue: | 5 | Start page/Pages: | 1706-1712 | Source: | Journal of Infectious Diseases | Abstract: | From January 1987 through December 1998, Penicillium marneffei infection (23 patients) or colonization (1 patient) was diagnosed in a total of 24 patients in Taiwan. Of these 24 patients, 16 (67%) had AIDS and 20 (83%) had disseminated P. marneffei infection. The majority (63%) of the infections were considered indigenous. The number of cases has increased markedly in recent years, with 17 of the 24 cases diagnosed from 1996 through 1998. Twenty preserved isolates of P. marneffei, recovered from 11 patients treated at National Taiwan University Hospital during the period of January 1996 through December 1998, were studied to determine the epidemiology of P. marneffei infections. Among the 20 isolates, a total of 8 strains (highly related isolates) were identified on the basis of tests for susceptibility to 5 antifungal agents, for chromosomal DNA restriction fragment-length polymorphism types, and for randomly amplified polymorphic DNA patterns. One of the strains (6 isolates) was isolated from 4 patients treated in 1997 and 1998. Strain spreading of P. marneffei may partially contribute to the increased number of infections caused by this organism in immunosuppressed patients in Taiwan. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0034090141&doi=10.1086%2f315432&partnerID=40&md5=37f09c8f439f6e4c314c013e4c7a17ce https://scholars.lib.ntu.edu.tw/handle/123456789/589030 |
ISSN: | 0022-1899 | DOI: | 10.1086/315432 | SDG/Keyword: | antifungal agent; acquired immune deficiency syndrome; adolescent; adult; article; clinical article; disease predisposition; female; human; immune deficiency; infant; male; mycosis; Penicillium marneffei; priority journal; restriction fragment length polymorphism; Taiwan; Adolescent; Adult; Antifungal Agents; Epidemiology, Molecular; Female; Genotype; Hospitals, University; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Mycoses; Penicillium; Phenotype; Taiwan |
Appears in Collections: | 醫學系 |
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