|Title:||Taiwan mini-frontier of primary aldosteronism: Updating treatment and comorbidities detection||Authors:||CHIEH-KAI CHAN
TAIPAI Study Group
|Keywords:||Comorbidities detection; Frontier; Primary aldosteronism; Treatment||Issue Date:||Oct-2021||Journal Volume:||120||Journal Issue:||10||Source:||Journal of the Formosan Medical Association = Taiwan yi zhi||Abstract:||
The aim of this study was to update the information on internationally acceptable standards and clinical practice recommendations for the management of patients with primary aldosteronism (PA). The Taiwan Society of Aldosteronism (TSA) Task Force acknowledged the novel issues of PA and reached a group consensus on PA in Taiwan by collecting the best available evidence and conducting one group meeting, several conference calls, and multiple e-mail communications. Unilateral adrenalectomy is the preferred treatment for patients with aldosterone-producing adenoma (APA). For medical treatment with mineralocorticoid receptor antagonists (MRAs), spironolactone is the first-line treatment, and eplerenone is a reasonable alternative in PA patients intolerant or contraindicated to spironolactone. The dose of MRAs can be titrated according to plasma renin activity (PRA). For screening PA-related comorbidities, we suggest albuminuria to predict a post-treatment decline in renal function, echocardiography as cardiac evaluation, bone mineral density scan for osteoporosis, and obstructive sleep apnea. In tissue and genetic surveys, we suggest immunohistochemical staining and somatic mutation screening for post-operative adrenal specimens in APA patients. With this consensus, we hope to update the information on PA for clinical physicians to facilitate better identification, management and treatment of patients with PA.
eplerenone; mineralocorticoid antagonist; spironolactone; spironolactone; adrenalectomy; albuminuria; bone density; comorbidity; consensus; controlled study; e-mail; echocardiography; health survey; human; immunohistochemistry; kidney function; osteoporosis; physician; plasma renin activity; postoperative care; practice guideline; primary hyperaldosteronism; Review; sleep disordered breathing; somatic mutation; Taiwan; treatment outcome; hyperaldosteronism; hypertension; Adrenalectomy; Humans; Hyperaldosteronism; Hypertension; Mineralocorticoid Receptor Antagonists; Spironolactone; Taiwan
|Appears in Collections:||醫學院附設醫院 (臺大醫院)|
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