https://scholars.lib.ntu.edu.tw/handle/123456789/590113
Title: | Adjuvant therapy may be omitted for oral cavity cancer with only one positive lymph node | Authors: | WAN-YU CHEN Fang, Ku Hao CHUN-WEI WANG Liao, Chun Ta Yen, Tzu Chen Fang, Taun Jen SHIH-FAN LAI HSIANG-KUANG LIANG |
Keywords: | adjuvant radiotherapy | oral cancer | risk factor | single node | surgery;adjuvant radiotherapy; oral cancer; risk factor; single node; surgery | Issue Date: | 1-Dec-2021 | Journal Volume: | 6 | Journal Issue: | 6 | Source: | Laryngoscope Investigative Otolaryngology | Abstract: | Objective: Whether to administer adjuvant treatment is a matter of great debate for oral cavity cancer harboring a single positive node without extranodal extension and positive margin (defined as low/intermediate risk pN1new in this study). Methods: A total of 243 low/intermediate risk pN1new patients with oral cavity cancer who received curative surgery were included. Overall survival (OS), local recurrence-free survival (LRFS), regional recurrence-free survival (RRFS), and distant metastasis-free survival (DMFS) were compared between patients receiving adjuvant treatment and observation alone. Results: For patients receiving adjuvant therapy vs observation, the differences in outcomes were not statistically significant in terms of 5-year OS, LRFS, RRFS, and DMFS. For subgroup analysis, in low/intermediate pN1new patients with one or more minor risk factors, adjuvant therapy was not significantly associated with OS, LRFS, RRFS, or DMFS in pN1new patients. Conclusion: For low/intermediate risk pN1new patients with oral cavity cancer, adjuvant therapy might be omitted. Level of Evidence: 4. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/590113 | ISSN: | 2378-8038 | DOI: | 10.1002/lio2.679 | SDG/Keyword: | cisplatin; adjuvant radiotherapy; adult; aged; Article; bone scintiscanning; cancer adjuvant therapy; cancer prognosis; cancer staging; cancer surgery; chemoradiotherapy; computer assisted tomography; distant metastasis free survival; female; human; intensity modulated radiation therapy; intermediate risk patient; local recurrence free survival; low risk patient; lymph node; lymph vessel metastasis; major clinical study; male; mouth cancer; multicenter study (topic); neck dissection; nuclear magnetic resonance imaging; overall survival; perineural invasion; positron emission tomography; proton therapy; radiation dose; recurrence free survival; regional recurrence free survival; retrospective study; risk assessment; risk factor; thorax radiography; volumetric modulated arc therapy |
Appears in Collections: | 醫學院附設醫院 (臺大醫院) |
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