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  1. NTU Scholars
  2. 醫學院
  3. 醫學院附設醫院 (臺大醫院)
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/590115
Title: Salvage Boron Neutron Capture Therapy for Malignant Brain Tumor Patients in Compliance with Emergency and Compassionate Use: Evaluation of 34 Cases in Taiwan
Authors: Chen, Yi-Wei
Lee, Yi-Yen
Lin, Chun-Fu
Pan, Po-Shen
Chen, Jen-Kun
CHUN-WEI WANG 
Hsu, Shih-Ming
Kuo, Yu-Cheng
Lan, Tien-Li
Hsu, Sanford P C
Liang, Muh-Lii
Chen, Robert Hsin-Hung
Chang, Feng-Chi
Wu, Chih-Chun
Lin, Shih-Chieh
Liang, Hsiang-Kuang
Lee, Jia-Cheng
Chen, Shih-Kuan
Liu, Hong-Ming
Peir, Jinn-Jer
Lin, Ko-Han
Huang, Wen-Sheng
Chen, Kuan-Hsuan
Kang, Yu-Mei
Liou, Shueh-Chun
Wang, Chun-Chieh
Pai, Ping-Ching
Li, Chih-Wei
Chiek, Daniel Quah Song
Wong, Tai-Tong
Chiou, Shih-Hwa
Chao, Yee
Tanaka, Hiroki
Chou, Fong-In
Ono, Koji
Keywords: BNCT; T/B ratio; T/N ratio; glioblastoma; radioresistance
Issue Date: 15-Apr-2021
Journal Volume: 10
Journal Issue: 4
Source: Biology
Abstract: 
Although boron neutron capture therapy (BNCT) is a promising treatment option for malignant brain tumors, the optimal BNCT parameters for patients with immediately life-threatening, end-stage brain tumors remain unclear. We performed BNCT on 34 patients with life-threatening, end-stage brain tumors and analyzed the relationship between survival outcomes and BNCT parameters. Before BNCT, MRI and 18F-BPA-PET analyses were conducted to identify the tumor location/distribution and the tumor-to-normal tissue uptake ratio (T/N ratio) of 18F-BPA. No severe adverse events were observed (grade ≥ 3). The objective response rate and disease control rate were 50.0% and 85.3%, respectively. The mean overall survival (OS), cancer-specific survival (CSS), and relapse-free survival (RFS) times were 7.25, 7.80, and 4.18 months, respectively. Remarkably, the mean OS, CSS, and RFS of patients who achieved a complete response were 17.66, 22.5, and 7.50 months, respectively. Kaplan-Meier analysis identified the optimal BNCT parameters and tumor characteristics of these patients, including a T/N ratio ≥ 4, tumor volume < 20 mL, mean tumor dose ≥ 25 Gy-E, MIB-1 ≤ 40, and a lower recursive partitioning analysis (RPA) class. In conclusion, for malignant brain tumor patients who have exhausted all available treatment options and who are in an immediately life-threatening condition, BNCT may be considered as a therapeutic approach to prolong survival.
URI: https://scholars.lib.ntu.edu.tw/handle/123456789/590115
ISSN: 2079-7737
DOI: 10.3390/biology10040334
metadata.dc.subject.other: [SDGs]SDG3
Appears in Collections:醫學院附設醫院 (臺大醫院)

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

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開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

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