https://scholars.lib.ntu.edu.tw/handle/123456789/590413
標題: | Combined effects of MMP-7, MMP-8 and MMP-26 on the risk of ischemic stroke | 作者: | Hsieh F.-I. Chiou H.-Y. Hu C.-J. JIANN-SHING JENG Lin H.-J. Lee J.-T. Lien L.-M. |
關鍵字: | Ischemic stroke; MMP-26; MMP-7; MMP-8; Weighted genetic risk score | 公開日期: | 2019 | 卷: | 8 | 期: | 11 | 起(迄)頁: | 2011 | 來源出版物: | Journal of Clinical Medicine | 摘要: | Ischemic stroke (IS) is multifactorial causation combining with traditional cardiovascular disease (CVD) and genetic risk factors. Combined effects of MMP-7, MMP-8 and MMP-26 on the risk of IS remain incompletely understood. We aimed to assess individual and joint effects for IS risk by weighted genetic risk score (wGRS) from these three genes and traditional CVD risk factors. A case-control study including 500 cases with IS and 500 stroke-free healthy controls frequency-matched with cases by age and sex was conducted. The wGRS was a weighted average of the number of risk genotype across selected SNPs from MMP-7, MMP-8 and MMP-26. Multivariate logistic regression models were used to analyze the relationship between wGRS and risk of IS. A wGRS in the second tertile was associated with a 1.5-fold increased risk of IS compared with the lowest tertile after adjusting for traditional CVD risk factors. Compared to subjects with low genetic and low modifiable CVD risk, those with high genetic and high modifiable CVD risk had the highest risk of IS (adjusted-OR = 5.75). In conclusion, higher wGRS was significantly associated with an increased risk for IS. A significant interaction between genetic and traditional CVD risk factors was also found on the risk of IS. ? 2019 by the authors. Licensee MDPI, Basel, Switzerland. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85092220656&doi=10.3390%2fjcm8112011&partnerID=40&md5=69c3c3835966961f0a9baaf098062916 https://scholars.lib.ntu.edu.tw/handle/123456789/590413 |
ISSN: | 20770383 | DOI: | 10.3390/jcm8112011 | SDG/關鍵字: | matrilysin; matrix metalloproteinase 26; neutrophil collagenase; adult; age; alcohol consumption; Article; brain ischemia; cardiovascular risk; case control study; controlled study; diabetes mellitus; female; gender; gene linkage disequilibrium; genetic risk; genetic variability; genotype; human; hypertension; major clinical study; male; middle aged; nucleotide sequence; obesity; polymerase chain reaction restriction fragment length polymorphism; scoring system; single nucleotide polymorphism; smoking; structured questionnaire; weighted Genetic Risk Score |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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