https://scholars.lib.ntu.edu.tw/handle/123456789/590444
標題: | Elevated Plasma Level of Soluble Form of RAGE in Ischemic Stroke Patients with Dementia | 作者: | SUNG-CHUN TANG KAI-CHIEN YANG Hu C.-J. Chiou H.-Y. CHAU-CHUNG WU JIANN-SHING JENG |
公開日期: | 2017 | 卷: | 19 | 期: | 4 | 起(迄)頁: | 579-583 | 來源出版物: | NeuroMolecular Medicine | 摘要: | The receptor for advanced glycation end products (RAGE) and its downstream pathways are involved in various inflammatory and immune responses. Importantly, there is soluble RAGE (sRAGE) that forms either by alternative splicing of RAGE messenger ribonucleic acid as the endogenous soluble form of RAGE (esRAGE) or by proteolytic cleavage of full-length RAGE protein. This study aimed to investigate the associations of the plasma levels of sRAGE and esRAGE in ischemic stroke (IS) patients with and without dementia. This cross-sectional study recruited patients with IS at a university medical center. Vascular dementia was defined as the scale of Clinical Dementia Ranking (CDR)???1. Standard enzyme-linked immunosorbent assay was used to measure the plasma concentration of sRAGE and esRAGE. From November 2014 to October 2015, a total of 172 IS patients (mean age: 72.1?±?7.5?years, 64.5% male) were recruited, including 73 with CDR?=?0, 63 with CDR?=?0.5, and 36 with CDR???1. In univariate analysis, IS patients with dementia were older and had more diabetes mellitus, less atrial fibrillation, and higher post-stroke modified Rankin Scale scores than those without dementia. Plasma levels of sRAGE and esRAGE were significantly higher in IS patients with than those without dementia (1.44?±?1.29 vs. 1.03?±?0.48 and 0.39?±?0.40 vs. 0.24?±?0.13?ng/mL, both p?0.01). Importantly, both parameters remained independent after adjustment for clinical variables (OR 2.683, p?=?0.013 and OR 39.192, p?=?0.006, respectively). In summary, plasma sRAGE and esRAGE were elevated in those with dementia compared with those without dementia among IS patients. ? 2017, The Author(s). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85032930784&doi=10.1007%2fs12017-017-8471-9&partnerID=40&md5=7b51b35fa4f55d41f9e847e01d53f60d https://scholars.lib.ntu.edu.tw/handle/123456789/590444 |
ISSN: | 15351084 | DOI: | 10.1007/s12017-017-8471-9 | SDG/關鍵字: | advanced glycation end product receptor; biological marker; biological marker; mitogen activated protein kinase; MOK protein, human; tumor antigen; aged; Article; atrial fibrillation; brain ischemia; Clinical Dementia Rating; cross-sectional study; diabetes mellitus; disease association; enzyme linked immunosorbent assay; female; human; major clinical study; male; multiinfarct dementia; priority journal; prospective study; protein blood level; Rankin scale; signal transduction; stroke patient; university hospital; blood; brain ischemia; cardiovascular disease; comorbidity; complication; dementia assessment; diabetes mellitus; hyperlipidemia; middle aged; multiinfarct dementia; risk factor; severity of illness index; smoking; solubility; very elderly; Aged; Aged, 80 and over; Antigens, Neoplasm; Biomarkers; Brain Ischemia; Cardiovascular Diseases; Comorbidity; Cross-Sectional Studies; Dementia, Vascular; Diabetes Mellitus; Female; Humans; Hyperlipidemias; Male; Mental Status and Dementia Tests; Middle Aged; Mitogen-Activated Protein Kinases; Prospective Studies; Risk Factors; Severity of Illness Index; Smoking; Solubility |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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