https://scholars.lib.ntu.edu.tw/handle/123456789/590565
標題: | Transcranial color-coded sonography helps differentiation between idiopathic Parkinson's disease and vascular parkinsonism | 作者: | Tsai C.-F. RUEY-MEEI WU Huang Y.-W. Chen L.-L. Yip P.-K. JIANN-SHING JENG |
公開日期: | 2007 | 卷: | 254 | 期: | 4 | 起(迄)頁: | 501-507 | 來源出版物: | Journal of Neurology | 摘要: | Background: Recently, transcranial color-coded sonography (TCCS) has been found to have a diagnostic value in patients with idiopathic Parkinson's disease (IPD), which displays increased hyperechogenicity at the substantia nigra (SN). Objective: To use TCCS, to assess the difference in SN hyperechogenicity and intracranial hemodynamics among subjects with IPD, vascular parkinsonism (VP) and controls. Methods: Eighty IPD and 30 VP patients, and 60 controls were recruited into this study. The hyperechogenicity area at the SN and midbrain were calculated by encircling the outer circumference from the ipsilateral temporal window, using TCCS in each subject. The hemodynamics of intracranial large arteries, including flow velocity and pulsatility index (PI), were also measured. Results: The presence of SN hyperechogenicity was significantly higher in the IPD patients than in the VP patients and controls (84% vs. 20% & 5%, respectively, p < 0.001). In IPD patients, the SN hyperechogenicity was correlated with the neurological severity and disease duration. Twenty-five (66.7%) VP patients had obvious vascular abnormality, as seen in TCCS study. The mean PI was significantly more elevated in the VP patients than those in the IPD patients and controls (all p < 0.05), but there was no significant difference of flow velocities among the VP, IPD patients and controls. Conclusions: TCCS, combining B-mode imaging for SN echogenicity and trancranial Doppler for intracranial hemodynamics, is a useful diagnostic tool in the differentiation between IPD and VP. These findings also suggest that multiple subcortical vascular lesions may damage the basal ganglia and thalamocortical circuit and result in parkinsonism features in VP patients. ? 2007 Steinkopff-Verlag. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-34249075719&doi=10.1007%2fs00415-006-0403-9&partnerID=40&md5=9d44d07183ff38c9fa3dd250b19516a6 https://scholars.lib.ntu.edu.tw/handle/123456789/590565 |
ISSN: | 3405354 | DOI: | 10.1007/s00415-006-0403-9 | SDG/關鍵字: | adult; aged; article; brain artery; controlled study; diagnostic value; differential diagnosis; disease duration; disease severity; Doppler echography; female; flow rate; hemodynamics; human; major clinical study; male; Parkinson disease; parkinsonism; priority journal; substantia nigra; Aged; Cerebrovascular Circulation; Female; Humans; Male; Middle Aged; Parkinson Disease; Parkinson Disease, Secondary; Retrospective Studies; Severity of Illness Index; Statistics, Nonparametric; Substantia Nigra; Ultrasonography, Doppler, Transcranial |
顯示於: | 醫學院附設醫院 (臺大醫院) |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。