https://scholars.lib.ntu.edu.tw/handle/123456789/590566
標題: | Transcranial imaging of substantia nigra hyperechogenicity in a Taiwanese cohort of Parkinson's disease | 作者: | Huang Y.-W. JIANN-SHING JENG Tsai C.-F. Chen L.-L. RUEY-MEEI WU |
公開日期: | 2007 | 卷: | 22 | 期: | 4 | 起(迄)頁: | 550-555 | 來源出版物: | Movement Disorders | 摘要: | Transcranial Doppler imaging (TCDI) has been used as a noninvasive diagnostic tool to differentiate Parkinson's disease (PD) from atypical parkinsonism by detecting hyperechogenicity in the substantia nigra (SN). To our knowledge, no TCDI data are available for Asian populations, and TCDI sensitivity is uncertain across populations. Early-onset PD (EOPD) represents a specific PD subtype based on clinical features and pathogenic mechanisms. It is not known if EOPD patients have abnormal echogenicity in SN comparable to late-onset PD (LOPD) patients. We assessed the area of SN hyperechogenicity (hyper-SN) and a ratio of hyper-SN over ipsilateral midbrain (S/M ratio) with TCDI in 164 healthy Taiwanese, 40 EOPD patients, and 40 LOPD patients. The upper 95th percentile values for hyper-SN and S/M ratio were 0.20 cm2 and 0.07. Our results indicate that S/M ratio is a more sensitive measure than hyper-SN in diagnosing PD. Approximately 92.5% of the LOPD patients and 57.5% of the EOPD patients had S/M ratios ? 0.07. Enlarged hyperechogenicity of SN is a common finding in LOPD, but not in EOPD. Iron-independent mechanisms of SN cell degeneration in EOPD distinct from that in LOPD might contribute to the sonographic findings. ? 2007 Movement Disorder Society. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-34247194127&doi=10.1002%2fmds.21372&partnerID=40&md5=f3d37fe615913d5752c98150cc8b359f https://scholars.lib.ntu.edu.tw/handle/123456789/590566 |
ISSN: | 8853185 | DOI: | 10.1002/mds.21372 | SDG/關鍵字: | iron; levodopa; adult; aged; article; cell degeneration; controlled study; demography; diagnostic accuracy; Doppler echography; female; human; major clinical study; male; mesencephalon; neuroimaging; onset age; Parkinson disease; priority journal; substantia nigra; Aged; Cohort Studies; Demography; Female; Humans; Male; Mesencephalon; Middle Aged; Observer Variation; Parkinson Disease; Severity of Illness Index; Substantia Nigra; Taiwan; Ultrasonography, Doppler, Transcranial |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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