https://scholars.lib.ntu.edu.tw/handle/123456789/591871
標題: | Solid pseudopapillary neoplasms of the pancreas: Is there a pathologic basis for the observed gender differences in incidence? | 作者: | YU-WEN TIEN Ser K.-H. REY-HENG HU CHIH-YUAN LEE YUNG-MING JENG PO-HUANG LEE |
公開日期: | 2005 | 卷: | 137 | 期: | 6 | 起(迄)頁: | 591-596 | 來源出版物: | Surgery | 摘要: | Background. The fact that solid pseudopapillary neoplasms of the pancreas (SPNP) occur predominantly in young women suggests that genetic and/or gender-specific factors may play a role in the pathogenesis. Therefore, SPNP derived from male patients may exhibit different molecular or clinicopathologic characteristics compared to SPNP derived from female patients. Methods. We compared the immunohistologic staining patterns and presence of sex hormone receptors of SPNP obtained from 4 male and 11 female patients. In addition, we analyzed the clinical data from 285 (21 male and 264 female) previously reported patients with SPNP and our 15 patients. Results. All 15 of the neoplasms were positive for progesterone, but negative for estrogen and androgen receptors. There were no immunohistologic differences between the genders. An analysis of all reported patients revealed no significant differences in patient age, size or location of the neoplasm, or malignancy rate. Conclusions. Although female patients with SPNP outnumbered male patients with SPNP, there were no gender-specific trends in expression of sex hormone receptor protein or clinicopathologic characteristics. ? 2005 Mosby, Inc. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-19944372463&doi=10.1016%2fj.surg.2005.01.015&partnerID=40&md5=c503e10cd659c3f4c5bcaf13a32a7a32 https://scholars.lib.ntu.edu.tw/handle/123456789/591871 |
ISSN: | 0039-6060 | DOI: | 10.1016/j.surg.2005.01.015 | SDG/關鍵字: | androgen receptor; estrogen; progesterone; sex hormone; adolescent; adult; article; cancer incidence; clinical article; comparative study; controlled study; female; gender; histopathology; human; human tissue; immunohistology; male; pancreas disease; pancreas solid pseudopapillary neoplasm; pancreas tumor; priority journal; protein expression; sample size; school child; sex difference; statistical significance; tumor localization; tumor volume; Adolescent; Adult; Child; Female; Humans; Immunohistochemistry; Incidence; Male; Pancreatic Neoplasms; Receptors, Androgen; Receptors, Estrogen; Receptors, Progesterone; Sex Distribution; Sex Factors; Staining and Labeling |
顯示於: | 醫學系 |
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