https://scholars.lib.ntu.edu.tw/handle/123456789/591922
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Hsieh, Chen-Hsi | en_US |
dc.contributor.author | Shueng, Pei-Wei | en_US |
dc.contributor.author | LI-YING WANG | en_US |
dc.contributor.author | Liao, Li-Jen | en_US |
dc.contributor.author | Lo, Wu-Chia | en_US |
dc.contributor.author | Yeh, Hsin-Pei | en_US |
dc.contributor.author | Chou, Hsiu-Ling | en_US |
dc.contributor.author | Wu, Le-Jung | en_US |
dc.date.accessioned | 2022-01-08T03:40:47Z | - |
dc.date.available | 2022-01-08T03:40:47Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 1073-2748 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/591922 | - |
dc.description.abstract | This study aimed to review clinical experiences using whole-field simultaneous integrated boost (SIB) intensity-modulated radiotherapy (IMRT) and sequential IMRT in postoperative patients with oral cavity cancer (OCC). From November 2006 to December 2014, a total of 182 postoperative patients with OCC who underwent either SIB-IMRT (n = 63) or sequential IMRT (n = 119) were enrolled retrospectively and matched randomly according to multiple risk factors by a computer. The differences were well balanced after patient matching (P = .38). The median follow-up time was 65 months. For patients treated with the SIB technique and the sequential technique, the respective mortality rates were 36.8% and 20.0% (P = .04). The primary recurrence rates were 26.3% and 10.0% (P = .02), respectively. The respective marginal failure rates were 26.7% and 16.7%. A multivariate logistic regression analysis showed that patients who received the SIB technique had a 2.74 times higher risk of death than those who received the sequential technique (95% confidence interval = 1.10-6.79, P = .03). Sequential IMRT provided a significantly lower dose to the esophagus (5.2 Gy, P = .02) and trachea (4.6 Gy, P = .03) than SIB-IMRT. For patients with locally advanced OCC, postoperative sequential IMRT may overcome an unpredictable geographic miss, potentially with a lower marginal failure rate in the primary area. Patients treated by sequential IMRT show equal overall survival benefits to those treated by SIB-IMRT and a lower mortality rate than those treated by SIB-IMRT. Additionally, a reduced dose to the esophagus and trachea compared to sequential IMRT was noted. | en_US |
dc.language.iso | en | en_US |
dc.publisher | SAGE PUBLICATIONS INC | en_US |
dc.relation.ispartof | Cancer control : journal of the Moffitt Cancer Center | en_US |
dc.subject | IMRT; SIB; dysphagia; oral cavity cancer; sequential | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | cisplatin; fluorouracil; folinic acid; Article; body weight loss; cancer chemotherapy; cancer surgery; confidence interval; controlled study; dysphagia; esophagus; experience; follow up; human; intensity modulated radiation therapy; major clinical study; mortality rate; mouth cancer; multivariate logistic regression analysis; radiation dose; recurrence risk; retrospective study; risk factor; sequential intensity modulated radiation therapy; thrombocytopenia; trachea; treatment failure; treatment outcome; whole field simultaneous integrated boost intensity modulated radiation therapy; cancer staging; clinical trial; female; intensity modulated radiation therapy; male; middle aged; mortality; mouth tumor; pathology; postoperative care; procedures; radiotherapy planning system; relative biologic effectiveness; survival rate; Dose Fractionation, Radiation; Female; Humans; Male; Middle Aged; Mouth Neoplasms; Neoplasm Staging; Postoperative Care; Radiotherapy Planning, Computer-Assisted; Radiotherapy, Intensity-Modulated; Relative Biological Effectiveness; Retrospective Studies; Survival Rate | - |
dc.title | Single-Institute Clinical Experiences Using Whole-Field Simultaneous Integrated Boost (SIB) Intensity-Modulated Radiotherapy (IMRT) and Sequential IMRT in Postoperative Patients With Oral Cavity Cancer (OCC) | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1177/1073274820904702 | - |
dc.identifier.pmid | 33047615 | - |
dc.identifier.scopus | 2-s2.0-85092544611 | - |
dc.identifier.isi | WOS:000582734500001 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85092544611 | - |
dc.relation.journalvolume | 27 | en_US |
dc.relation.journalissue | 1 | en_US |
item.languageiso639-1 | en | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Physical Therapy | - |
crisitem.author.orcid | 0000-0003-3075-6872 | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 物理治療學系所 |
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