https://scholars.lib.ntu.edu.tw/handle/123456789/591991
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | CHENG-HONG TSAI | en_US |
dc.contributor.author | JIH-LUH TANG | en_US |
dc.contributor.author | FENG-MING TIEN | en_US |
dc.contributor.author | YUAN-YEH KUO | en_US |
dc.contributor.author | Wu D.-C. | en_US |
dc.contributor.author | CHIEN-CHIN LIN | en_US |
dc.contributor.author | Tseng M.-H. | en_US |
dc.contributor.author | Peng Y.-L. | en_US |
dc.contributor.author | Hou M.-F. | en_US |
dc.contributor.author | Chuang Y.-K. | en_US |
dc.contributor.author | Liu M.-C. | en_US |
dc.contributor.author | CHIA-WEN LIU | en_US |
dc.contributor.author | MING YAO | en_US |
dc.contributor.author | LIANG-IN LIN | en_US |
dc.contributor.author | WEN-CHIEN CHOU | en_US |
dc.contributor.author | CHIEN-YU CHEN | en_US |
dc.contributor.author | HSIN-AN HOU | en_US |
dc.contributor.author | HWEI-FANG TIEN | en_US |
dc.date.accessioned | 2022-01-10T08:54:12Z | - |
dc.date.available | 2022-01-10T08:54:12Z | - |
dc.date.issued | 2021-05-17 | - |
dc.identifier.issn | 24739529 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/591991 | - |
dc.description.abstract | Next-generation sequencing (NGS) has been applied to measurable/minimal residual disease (MRD) monitoring after induction chemotherapy in patients with acute myeloid leukemia (AML), but the optimal time point for the test remains unclear. In this study, we aimed to investigate the clinical significance of NGS MRD at 2 different time points. We performed targeted NGS of 54 genes in bone marrow cells serially obtained at diagnosis, first complete remission (first time point), and after the first consolidation chemotherapy (second time point) from 335 de novo AML patients. Excluding DNMT3A, TET2, and ASXL1 mutations, which are commonly present in individuals with clonal hematopoiesis of indeterminate potential, MRD could be detected in 46.4% of patients at the first time point (MRD1st), and 28.9% at the second time point (MRD2nd). The patients with detectable NGS MRD at either time point had a significantly higher cumulative incidence of relapse and shorter relapse-free survival and overall survival. In multivariate analysis, MRD1st and MRD2nd were both independent poor prognostic factors. However, the patients with positive MRD1st but negative MRD2nd had a similar good prognosis as those with negative MRD at both time points. The incorporation of multiparameter flow cytometry and NGS MRD revealed that the presence of NGS MRD predicted poorer prognosis among the patients without detectable MRD by multiparameter flow cytometry at the second time point but not the first time point. In conclusion, the presence of NGS MRD, especially after the first consolidation therapy, can help predict the clinical outcome of AML patients. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Blood Advances | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | DNA methyltransferase 3A; transcription factor RUNX1; acute myeloid leukemia; adolescent; adult; age; aged; Article; ASXL1 gene; bone marrow cell; cancer chemotherapy; cancer prognosis; cancer survival; CEBPA gene; clinical feature; clinical outcome; cohort analysis; consolidation chemotherapy; controlled study; DNMT3A gene; female; flow cytometry; gene; gene mutation; high throughput sequencing; human; human cell; incidence; leukemia relapse; leukemia remission; major clinical study; male; minimal residual disease; monitoring; overall survival; prediction; recurrence free survival; retrospective study; RUNX1 gene; TET2 gene | - |
dc.title | Clinical implications of sequential MRD monitoring by NGS at 2 time points after chemotherapy in patients with AML | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1182/BLOODADVANCES.2020003738 | - |
dc.identifier.pmid | 33999144 | - |
dc.identifier.scopus | 2-s2.0-85107182727 | - |
dc.identifier.url | https://scholars.lib.ntu.edu.tw/handle/123456789/571083 | - |
dc.relation.pages | 2456 | en_US |
dc.relation.journalvolume | 5 | en_US |
dc.relation.journalissue | 10 | en_US |
dc.relation.pageend | 2466 | en_US |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Oncology | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Laboratory Medicine-NTUH | - |
crisitem.author.dept | Accounting | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Integrated Diagnostics and Therapeutics-NTUH | - |
crisitem.author.dept | Clinical Laboratory Sciences and Medical Biotechnology | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Laboratory Medicine-NTUH | - |
crisitem.author.dept | Biomechatronics Engineering | - |
crisitem.author.dept | Center for Biotechnology | - |
crisitem.author.dept | Genome and Systems Biology Degree Program | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-4174-8766 | - |
crisitem.author.orcid | 0000-0003-4021-3281 | - |
crisitem.author.orcid | 0000-0003-4513-2472 | - |
crisitem.author.orcid | 0000-0002-6090-9000 | - |
crisitem.author.orcid | 0000-0001-7160-2285 | - |
crisitem.author.orcid | 0000-0003-2932-0019 | - |
crisitem.author.orcid | 0000-0002-3561-1093 | - |
crisitem.author.orcid | 0000-0003-2967-698X | - |
crisitem.author.orcid | 0000-0002-6940-6389 | - |
crisitem.author.orcid | 0000-0003-2780-4845 | - |
crisitem.author.orcid | 0000-0002-1384-5593 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Management | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
crisitem.author.parentorg | Others: University-Level Research Centers | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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