https://scholars.lib.ntu.edu.tw/handle/123456789/592023
標題: | Lipidomics of children and adolescents exposed to multiple industrial pollutants | 作者: | CHI-HSIN SALLY CHEN Kuo, Tien-Chueh Kuo, Han-Chun CHING-HUA KUO Yuan, Tzu-Hsuen YUFENG JANE TSENG CHANG-CHUAN CHAN |
關鍵字: | Children's health; Lipidomics; Multiple toxics exposure; Petrochemical industry | 公開日期: | 2021 | 出版社: | ACADEMIC PRESS INC ELSEVIER SCIENCE | 卷: | 201 | 來源出版物: | Environmental Research | 摘要: | Background: There are limited studies on the lipidomics of children and adolescents exposed to multiple industrial pollutants. Objectives: In this study, we aimed to investigate lipid profile perturbations in 99 children and adolescents (aged 9–15) who lived in a polluted area surrounding the largest petrochemical complex in Taiwan. Previous studies have reported increased risks of acute and chronic diseases including liver dysfunctions and chronic kidney disease (CKD) in residents living in this area. Methods: We measured urinary concentrations of 11 metals and metalloids and polycyclic aromatic hydrocarbons (PAHs) metabolite 1-hydroxypyrene (1-OHP) as exposure biomarkers, and urinary oxidative stress biomarkers and serum acylcarnitines as early health effect biomarkers. The association between individual exposure biomarkers and early health effect biomarkers were analyzed using linear regression, while association of combined exposure biomarkers with four oxidative stress biomarkers and acylcarnitines were analyzed using weighted quantile sum (WQS) regression. Lipid profiles were analyzed using an untargeted liquid chromatography mass spectrometry-based technique. “Meet-in-the-middle” approach was applied to identify potential lipid features that linked multiple industrial pollutants exposure with early health effects. Results: We identified 15 potential lipid features that linked elevated multiple industrial pollutants exposure with three increased oxidative stress biomarkers and eight deregulated serum acylcarnitines, including one lysophosphatidylcholines (LPCs), four phosphatidylcholines (PCs), and two sphingomyelins (SMs) that were up-regulated in high exposure group compared to low exposure group, and two LPCs, four PCs, and two phosphatidylinositols (PIs) down-regulated in high exposure group compared to low exposure group. Conclusion: Our findings could provide information for understanding the health effects, including early indicators and biological mechanism identification, of children and adolescents exposed to multiple industrial pollutants during critical stages of development. © 2021 The Authors |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/592023 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108350263&doi=10.1016%2fj.envres.2021.111448&partnerID=40&md5=659f6d41d428474949589de3e80a7232 |
ISSN: | 00139351 | DOI: | 10.1016/j.envres.2021.111448 | SDG/關鍵字: | 1 hydroxypyrene; acylcarnitine; arsenic; biological marker; cadmium; chromium; copper; environmental, industrial and domestic chemicals; glycerophospholipid; lead; lysophosphatidylcholine; manganese; mercury; nickel; phosphatidylcholine; phosphatidylinositol; polycyclic aromatic hydrocarbon; sphingolipid; sphingomyelin; strontium; thallium; vanadium; polycyclic aromatic hydrocarbon; adolescence; biomarker; chemical pollutant; industrial waste; lipid; liquid chromatography; metabolite; oxidative stress; PAH; pollution exposure; adolescent; Article; body mass; child; chronic kidney failure; controlled study; cross-sectional study; drinking behavior; environmental exposure; enzyme linked immunosorbent assay; estimated glomerular filtration rate; female; geographic information system; high performance liquid chromatography; human; human tissue; inductively coupled plasma mass spectrometry; kidney concentrating capacity; lipid blood level; lipid fingerprinting; lipidomics; liquid chromatography-mass spectrometry; liver dysfunction; major clinical study; male; method detection limit; oxidative stress; petrochemical industry; risk factor; school child; Taiwan; urinalysis; adverse event; environmental exposure; industry; lipidomics; pollutant; toxicity; Taiwan; Adolescent; Biomarkers; Child; Environmental Exposure; Environmental Pollutants; Humans; Industry; Lipidomics; Polycyclic Aromatic Hydrocarbons |
顯示於: | 公共衛生碩士學位學程 |
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