https://scholars.lib.ntu.edu.tw/handle/123456789/592032
標題: | Temporal Correlations of Skin and Blood Metabolites with Clinical Outcomes of Biologic Therapy in Psoriasis | 作者: | Dutkiewicz E.P. Hsieh K.-T. Urban P.L. HSIEN-YI CHIU |
公開日期: | 2020 | 出版社: | NLM (Medline) | 卷: | 5 | 期: | 5 | 起(迄)頁: | 877-888 | 來源出版物: | The journal of applied laboratory medicine | 摘要: | BACKGROUND: Psoriasis is an inflammatory skin disease causing multisystem effects. Introduction of biologic drugs has led to promising results in treatment of this disease. Here, we carry out time-dependent profiling of psoriasis-related putative metabolic biomarkers. METHODS: Skin excretion specimens were collected from 17 patients with psoriasis treated with biologics for 7?months. Blood specimens were obtained from the same patients at intervals of 1-3?months. A hydrogel micropatch sampling technique was implemented to collect lesional (L) and nonlesional (NL) skin specimens. The collected skin and blood specimens were analyzed by mass spectrometric methods. RESULTS: The metabolites present on L skin-in particular, choline, and citrulline-showed greater dynamics, corresponding to the resolution of psoriasis than the metabolites present in NL skin or blood. Choline levels in L skin and blood correlated positively, while citrulline correlated negatively with the severity of individual psoriasis plaques and general disease severity, respectively. Nevertheless, the correlations between the metabolite levels in blood and general disease severity were weaker than those between the metabolite levels on L skin and severity of individual plaques. The changes of these skin metabolites were more prominent in the responders to the treatment than in the nonresponders. CONCLUSIONS: The results support the feasibility of characterizing dynamic changes in psoriatic skin metabolic pro?les with the hydrogel micropatch probes and mass spectrometric tests. The study represents one of few attempts to explore relationships between skin and blood metabolite concentrations. However, practical use of the methodology in close clinical monitoring is yet to be demonstrated. ? American Association for Clinical Chemistry 2020. All rights reserved. For permissions, please email: journals.permissions@oup.com. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090872731&doi=10.1093%2fjalm%2fjfaa009&partnerID=40&md5=d87e2dc6aa7fb3c45fe173da02c5d875 https://scholars.lib.ntu.edu.tw/handle/123456789/592032 |
ISSN: | 2576-9456 | DOI: | 10.1093/jalm/jfaa009 | SDG/關鍵字: | biological therapy; human; metabolism; psoriasis; severity of illness index; skin; Biological Therapy; Humans; Psoriasis; Severity of Illness Index; Skin |
顯示於: | 醫學系 |
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