https://scholars.lib.ntu.edu.tw/handle/123456789/592048
標題: | Noninvasive glucose monitoring with a contact lens and smartphone | 作者: | Lin Y.-R. Hung C.-C. HSIEN-YI CHIU Chang B.-H. Li B.-R. Cheng S.-J. Yang J.-W. Lin S.-F. Chen G.-Y. |
關鍵字: | Contact lens; Glucose monitoring; Image detection; Noninvasive; Smartphone | 公開日期: | 2018 | 出版社: | MDPI AG | 卷: | 18 | 期: | 10 | 來源出版物: | Sensors (Switzerland) | 摘要: | Diabetes has become a chronic metabolic disorder, and the growing diabetes population makes medical care more important. We investigated using a portable and noninvasive contact lens as an ideal sensor for diabetes patients whose tear fluid contains glucose. The key feature is the reversible covalent interaction between boronic acid and glucose, which can provide a noninvasive glucose sensor for diabetes patients. We present a phenylboronic acid (PBA)-based HEMA contact lens that exhibits a reversible swelling/shrinking effect to change its thickness. The difference in thickness can be detected in a picture taken with a smartphone and analyzed using software. Our novel technique offers the following capabilities: (i) non-enzymatic and continuous glucose detection with the contact lens; (ii) no need for an embedded circuit and power source for the glucose sensor; and (iii) the use of a smartphone to detect the change in thickness of the contact lens with no need for additional photo-sensors. This technique is promising for a noninvasive measurement of the glucose level and simple implementation of glucose sensing with a smartphone. ? 2018 by the authors. Licensee MDPI, Basel, Switzerland. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85053816375&doi=10.3390%2fs18103208&partnerID=40&md5=e01da50a88891c59e4a468a74d57c5b1 https://scholars.lib.ntu.edu.tw/handle/123456789/592048 |
ISSN: | 1424-8220 | DOI: | 10.3390/s18103208 | SDG/關鍵字: | Contact lenses; Glucose sensors; mHealth; Smartphones; Change in thickness; Covalent interactions; Glucose monitoring; Image detection; Metabolic disorders; Noninvasive; Noninvasive glucose monitoring; Noninvasive measurements; Glucose; glucose; blood glucose monitoring; chemistry; contact lens; devices; human; lacrimal fluid; procedures; smartphone; Blood Glucose Self-Monitoring; Contact Lenses; Glucose; Humans; Smartphone; Tears |
顯示於: | 醫學系 |
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