https://scholars.lib.ntu.edu.tw/handle/123456789/592155
標題: | Is the risk of second primary malignancy increased in multiple myeloma in the novel therapy era? A population-based, retrospective cohort study in Taiwan | 作者: | Liu Y. HSIN-AN HOU Qiu H. Tang C.-H. |
公開日期: | 2020 | 出版社: | Nature Research | 卷: | 10 | 期: | 1 | 來源出版物: | Scientific Reports | 摘要: | Longer survival in patients with multiple myeloma (MM) after treatment with novel agents (NA) such as thalidomide, bortezomib, and lenalidomide may be associated with increased risks of developing second primary malignancies (SPM). Few data describe the risk of SPM in patients with MM in Asia. This population-based retrospective cohort study assessed the risk of SPM in MM using the Taiwan National Cancer Registry and National Health Insurance Research databases from 2000 to 2014. Among 4,327 patients with newly diagnosed MM initiated with either novel agents alone (NA), chemotherapy combined with novel agents (CCNA), or chemotherapy alone (CA), the cumulative incidence of SPM overall was 1.33% at year 3. The SPM incidence per 100 person-years (95%?confidence interval [CI]) was 0.914 (0.745–1.123) overall, 0.762 (0.609–1.766) for solid tumours, and 0.149 (0.090–0.247) for haematological malignancies. We compared risks of SPM using a cause-specific Cox regression model considering death as a competing risk for developing SPM. After controlling for age, gender, Charlson Co-morbidity Index, and time-period, the risk of developing any SPM or any haematological malignancy was significantly reduced in patients initiated on NA (2010–2014 period) compared to chemotherapy alone (adjusted hazard ratio 0.24, 95%?CI 0.07–0.85, and 0.10, 95%?CI 0.02–0.62, respectively). Contemporary treatment regiments using NA (mainly bortezomib) were associated with a lower risk for a SPM in comparison with CA. ? 2020, The Author(s). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090051831&doi=10.1038%2fs41598-020-71243-z&partnerID=40&md5=3e703aef10a4946082d0ef4f496d90e2 https://scholars.lib.ntu.edu.tw/handle/123456789/592155 |
ISSN: | 2045-2322 | DOI: | 10.1038/s41598-020-71243-z | SDG/關鍵字: | antineoplastic agent; bortezomib; lenalidomide; thalidomide; aged; female; follow up; hematologic disease; human; incidence; male; middle aged; multiple myeloma; register; retrospective study; risk factor; second cancer; Taiwan; treatment outcome; very elderly; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bortezomib; Female; Follow-Up Studies; Hematologic Neoplasms; Humans; Incidence; Lenalidomide; Male; Middle Aged; Multiple Myeloma; Neoplasms, Second Primary; Registries; Retrospective Studies; Risk Factors; Taiwan; Thalidomide; Treatment Outcome |
顯示於: | 醫學系 |
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