|Title:||Mechanotransduction in fibrosis: Mechanisms and treatment targets||Authors:||CHIH-FAN YEH
|Keywords:||Fibrosis; Mechanotransduction; Nucleocytoskeletal coupling; YAP/TAZ||Issue Date:||5-Oct-2021||Publisher:||San Diego : Academic Press||Journal Volume:||87||Start page/Pages:||279||Source:||Current topics in membranes||Abstract:||
To perceive and integrate the environmental cues, cells and tissues sense and interpret various physical forces like shear, tensile, and compression stress. Mechanotransduction involves the sensing and translation of mechanical forces into biochemical and mechanical signals to guide cell fate and achieve tissue homeostasis. Disruption of this mechanical homeostasis by tissue injury elicits multiple cellular responses leading to pathological matrix deposition and tissue stiffening, and consequent evolution toward pro-inflammatory/pro-fibrotic phenotypes, leading to tissue/organ fibrosis. This review focuses on the molecular mechanisms linking mechanotransduction to fibrosis and uncovers the potential therapeutic targets to halt or resolve fibrosis.
|Appears in Collections:||醫學系|
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