https://scholars.lib.ntu.edu.tw/handle/123456789/592684
標題: | Regulation of IAPs gene family by interleukin-1α and Epstein-Barr virus in nasopharyngeal carcinoma | 作者: | Chua H.-H. TE-HUEI YEH Wang Y.-P. Sheen T.-S. Shew J.-Y. Huang Y.-T. CHING-HWA TSAI |
公開日期: | 2008 | 卷: | 30 | 期: | 12 | 起(迄)頁: | 1575-1585 | 來源出版物: | Head and Neck | 摘要: | Background. Inhibitors of apoptosis proteins (IAPs), which counteract apoptosis by potently inhibiting caspase activation, are promising targets of new anti-tumor therapy. However, their roles in the pathogenesis of nasopharyngeal carcinoma (NPC), an Epstein-Barr virus (EBV)-associated carcinoma, are not fully understood. Herein, we investigated the expression and regulation of IAPs in NPC. Methods and Results. Using real-time quantitative polymerase chain reaction (PCR) analysis, we found that among the IAPs family only the transcription of survivin, HIAP-1, and HIAP-2 was consistently up-regulated in NPC and metastatic NPC tissues. Immunohistochemical staining showed that their proteins were more predominantly expressed in tumor cells nests. Noteworthy, these IAPs were upregulated by interleukin-1α stimulation or EBV infection, and subsequently resulted in triggering rapid proliferation of NPC verified by strong Ki-67 staining. Conclusion. Survivin, HIAP-1, and HIAP-2 were distinctly upregulated in NPC, suggesting they may play significant roles in NPC tumorigenesis and serve as tumor markers with prognostic and therapeutic implications. ? 2008 Wiley Periodicals, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-57349194636&doi=10.1002%2fhed.20896&partnerID=40&md5=ee64ac6020228f360f24cc2d7e420ad6 https://scholars.lib.ntu.edu.tw/handle/123456789/592684 |
ISSN: | 1043-3074 | DOI: | 10.1002/hed.20896 | SDG/關鍵字: | inhibitor of apoptosis protein 1; inhibitor of apoptosis protein 2; interleukin 1alpha; Ki 67 antigen; survivin; apoptosis; article; carcinogenesis; cell proliferation; clinical article; controlled study; disease marker; Epstein Barr virus; gene control; genetic transcription; human; human tissue; immunohistochemistry; metastasis; nasopharynx carcinoma; pathogenesis; priority journal; prognosis; protein expression; reverse transcription polymerase chain reaction; upregulation; Apoptosis; Carcinoma, Squamous Cell; Caspases; Epstein-Barr Virus Infections; Herpesvirus 4, Human; Humans; Inhibitor of Apoptosis Proteins; Interleukin-1alpha; Microtubule-Associated Proteins; Nasopharyngeal Neoplasms; Polymerase Chain Reaction; Tumor Markers, Biological |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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