https://scholars.lib.ntu.edu.tw/handle/123456789/592686
標題: | Upregulation of discoidin domain receptor 2 in nasopharyngeal carcinoma | 作者: | Chua H.-H. TE-HUEI YEH Wang Y.-P. Huang Y.-T. Sheen T.-S. Lo Y.-C. Chou Y.-C. CHING-HWA TSAI |
公開日期: | 2008 | 卷: | 30 | 期: | 4 | 起(迄)頁: | 427-436 | 來源出版物: | Head and Neck | 摘要: | Background. Nasopharyngeal carcinoma (NPC) is associated with Epstein-Barr virus (EBV) and has high metastatic potential. Discoidin domain receptors (DDR1, DDR2) are receptor-type tyrosine kinases activated by collagen. Their ability to induce expression of matrix metalloproteinase is related with tumor invasion. Therefore, we aim to investigate DDRs gene expression and its regulation in NPC. Methods and Results. By use of real-time quantitative polymerase chain reaction (Q-PCR), DDR2 gene expression but not DDR1 was significantly higher in primary and metastatic NPC. DDR2 was predominantly distributed in NPC tumor cells rather than in infiltrating lymphocytes. EBV Z-transactivator (Zta) transfection may distinctly elevate DDR2 level. Furthermore, data from reporter assay indicate that Zta could transactivate DDR2 promoter activity, suggesting the possible upregulation mechanism. Conclusion. DDR2 was differentially upregulated in NPC and modulated by EBV Zta protein. DDR2 may play a role in NPC invasion and serve as a diagnostic and therapeutic target. ? 2007 Wiley Periodicals, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-42549099331&doi=10.1002%2fhed.20724&partnerID=40&md5=03f983527cee9c87ddc882a7bdf6f449 https://scholars.lib.ntu.edu.tw/handle/123456789/592686 |
ISSN: | 1043-3074 | DOI: | 10.1002/hed.20724 | SDG/關鍵字: | discoidin domain receptor 1; discoidin domain receptor 2; immediate early protein BZLF1; tyrosine kinase receptor; unclassified drug; article; cancer cell; cancer invasion; controlled study; diagnostic value; Epstein Barr virus; gene expression regulation; gene function; genetic transfection; human; human tissue; lymphocytic infiltration; metastasis; nasopharynx carcinoma; priority journal; promoter region; real time polymerase chain reaction; receptor upregulation; reporter gene; virus carcinogenesis; Carcinoma; Epithelial Cells; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Lymphocytes; Nasopharyngeal Neoplasms; Polymerase Chain Reaction; Receptor Protein-Tyrosine Kinases; Receptors, Mitogen; Trans-Activators; Transcription, Genetic; Up-Regulation; Viral Proteins |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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