https://scholars.lib.ntu.edu.tw/handle/123456789/592750
標題: | Randomized controlled trial of probiotic ps128 in children with tourette syndrome | 作者: | Wu C.-C. LEE-CHIN WONG Hsu C.-J. Yang C.-W. Tsai Y.-C. Cheng F.-S. Hu H.-Y. WANG-TSO LEE |
公開日期: | 2021 | 出版社: | MDPI | 卷: | 13 | 期: | 11 | 起(迄)頁: | 3698 | 來源出版物: | Nutrients | 摘要: | Tourette syndrome results from a complex interaction between social–environmental factors, multiple genetic abnormalities, and neurotransmitter disturbances. This study is a double-blinded, randomized controlled trial using probiotics Lactobacillus plantarum PS128 as an intervention to examine if probiotics improve symptoms of children with Tourette syndrome. This study enrolled children aged 5 to 18 years old who fulfilled DSM-V diagnostic criteria for Tourette syndrome. Patients were assessed before initiating the trial, at one month, and at two months after randomization. The primary outcome was evaluated by Yale Global Tic Severity Scale (YGTSS), and the secondary outcome studied the possible comorbidities in these children. The results revealed no significant difference in improvement in YGTSS between the control group and the PS128 group. As for secondary endpoints, an analysis of Conners’ Continuous Performance Test (CPT) showed improvement in commission and detectability in the PS128 group. In conclusion, although probiotics may not have tic-reducing effects in children with Tourette syndrome, it may have benefits on comorbidities such as attention deficit and hyperactivity disorder (ADHD). Further studies are needed to clarify the effects of probiotics on the comorbidities of Tourette syndrome children. ? 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117332661&doi=10.3390%2fnu13113698&partnerID=40&md5=2e48e974a1c16c0a6f7595bb09b1a745 https://scholars.lib.ntu.edu.tw/handle/123456789/592750 |
ISSN: | 2072-6643 | DOI: | 10.3390/nu13113698 | SDG/關鍵字: | placebo; probiotic agent; probiotic agent; adolescent; adult; Article; attention deficit disorder; child; comorbidity; continuous performance test; controlled study; double blind procedure; DSM-5; female; Gilles de la Tourette syndrome; human; Lactobacillus plantarum; major clinical study; male; motor dysfunction assessment; outcome assessment; randomized controlled trial; Yale Global Tic Severity Scale; complication; follow up; Gilles de la Tourette syndrome; obsessive compulsive disorder; questionnaire; Child; Comorbidity; Female; Follow-Up Studies; Humans; Male; Obsessive-Compulsive Disorder; Outcome Assessment, Health Care; Placebos; Probiotics; Surveys and Questionnaires; Tourette Syndrome |
顯示於: | 醫學系 |
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