https://scholars.lib.ntu.edu.tw/handle/123456789/593088
標題: | Asian consensus on the relationship between obesity and gastrointestinal and liver diseases | 作者: | Koh J.C. Loo W.M. Goh K.L. Sugano K. Chan W.K. Chiu W.Y.P. Choi M.-G. Gonlachanvit S. Lee W.-J. Lee W.J.J. Lee Y.Y. Lesmana L.A. Li Y.-M. CHUN-JEN LIU Matsuura B. Nakajima A. Ng E.K.W. Sollano J.D. Wong S.K.H. Wong V.W.S. Yang Y. Ho K.Y. Dan Y.Y. |
關鍵字: | Barrett's esophagus; carcinogenesis and metastasis; clinical; clinical; esophageal neoplasms; gastric cancer: epidemiology and surveillance; hepatocellular carcinoma; microbial pathogenesis; NAFLD; pancreatic cancer | 公開日期: | 2016 | 出版社: | Blackwell Publishing | 卷: | 31 | 期: | 8 | 起(迄)頁: | 1405-1413 | 來源出版物: | Journal of Gastroenterology and Hepatology (Australia) | 摘要: | The incidence of obesity is increasing in Asia, with implications on gastrointestinal (GI) and liver diseases. The Gut and Obesity in Asia Workgroup comprises regional experts with the aim of studying relationship between obesity and the GI and liver diseases in Asia. Through literature review and the modified Delphi process, consensus statements examining the impact of obesity on esophageal, gastric, pancreatic, colorectal, and liver diseases, exploring relationship between gut microbiome and obesity, and assessing obesity therapies have been produced by the Gut and Obesity in Asia Workgroup. Sixteen experts participated with 9/15 statements having strong consensus (>80% agreement). The prevalence of obesity in Asia is increasing (100% percentage agreement in brackets), and this increased prevalence of obesity will result in a greater burden of obesity-related GI and liver diseases (93.8%). There was consensus that obesity increases the risk of gastric cancer (75%) and colorectal neoplasia (87.5%). Obesity was also associated with Barrett's esophagus and esophageal adenocarcinoma (66.7%) and pancreatic cancer (66.7%) in Asia. The prevalence of non-alcoholic fatty liver disease (NAFLD) in Asia is on the rise (100%), and the risk of NAFLD in Asia (100%) is increased by obesity. Obesity is a risk factor for the development of hepatocellular carcinoma (93.8%). Regarding therapy, it was agreed that bariatric surgery was an effective treatment modality for obesity (93.8%) but there was less agreement on its benefit for NAFLD (62.5%). These experts' consensus on obesity and GI diseases in Asia forms the basis for further research, and its translation into addressing this emerging issue. ? 2016 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84984595831&doi=10.1111%2fjgh.13385&partnerID=40&md5=5623c57b95c9f3f40afed0fb5fd57d82 https://scholars.lib.ntu.edu.tw/handle/123456789/593088 |
ISSN: | 0815-9319 | DOI: | 10.1111/jgh.13385 | SDG/關鍵字: | Asia; bariatric surgery; Barrett esophagus; cancer risk; clinical effectiveness; colorectal disease; colorectal tumor; consensus; disease association; disease predisposition; esophageal adenocarcinoma; esophagus disease; human; intestine flora; liver cell carcinoma; liver disease; medical expert; meta analysis (topic); nonalcoholic fatty liver; obesity; pancreas cancer; pancreas disease; prevalence; priority journal; Review; stomach cancer; stomach disease; systematic review (topic); Asian continental ancestry group; consensus; consensus development; Delphi study; evidence based medicine; Gastrointestinal Diseases; gastrointestinal tract; incidence; Liver Diseases; microbiology; obesity; prognosis; risk assessment; risk factor; Asia; Asian Continental Ancestry Group; Consensus; Delphi Technique; Evidence-Based Medicine; Gastrointestinal Diseases; Gastrointestinal Microbiome; Gastrointestinal Tract; Humans; Incidence; Liver Diseases; Obesity; Prevalence; Prognosis; Risk Assessment; Risk Factors |
顯示於: | 臨床醫學研究所 |
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