https://scholars.lib.ntu.edu.tw/handle/123456789/593238
標題: | Hepatitis B virus-related hepatocellular carcinoma: Epidemiology and pathogenic role of viral factors | 作者: | CHUN-JEN LIU JIA-HORNG KAO |
公開日期: | 2007 | 出版社: | Chinese Medical Association - Taipei | 卷: | 70 | 期: | 4 | 起(迄)頁: | 141-145 | 來源出版物: | Journal of the Chinese Medical Association | 摘要: | Chronic hepatitis B virus (HBV) infection is the primary risk factor for the development of hepatocellular carcinoma worldwide. After decades of chronic hepatitis, about 30-40% of patients progress into liver cirrhosis, and of them, around 1-5% subsequently develop hepatocellular carcinoma (HCC) annually. Since the carcinogenic process involves the interplay between the hepatitis virus and the host hepatocytes, both genomes contribute to the final pathogenic outcome, either individually or synergistically. Studying the genetic factors predisposing hepatocarcinogenesis in both host and viral genomes will help illuminate the critical carcinogenic mechanisms, and create molecular targets for future therapy. In this article, we thus review the epidemiology of HBV-related HCC and viral factors involved in hepatocarcinogenesis. ? 2007 Elsevier. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-34248995566&doi=10.1016%2fS1726-4901%2809%2970346-6&partnerID=40&md5=eab09d223cfdfcfa5974106438e427de https://scholars.lib.ntu.edu.tw/handle/123456789/593238 |
ISSN: | 1726-4901 | DOI: | 10.1016/S1726-4901(09)70346-6 | SDG/關鍵字: | hepatitis B surface antigen; hepatitis B vaccine; cancer incidence; cancer risk; chronic hepatitis; gene mutation; genetic association; genetic predisposition; genome analysis; genotype; geographic distribution; hepatitis B; Hepatitis B virus; heredity; host pathogen interaction; human; liver carcinogenesis; liver cell; liver cell carcinoma; liver cirrhosis; malignant transformation; mass immunization; nonhuman; onset age; pathogenesis; review; risk assessment; risk factor; sex difference; Taiwan; trend study; virus gene; virus load; virus virulence |
顯示於: | 臨床醫學研究所 |
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