https://scholars.lib.ntu.edu.tw/handle/123456789/593654
Title: | Facilitating drug delivery in the central nervous system by opening the blood-cerebrospinal fluid barrier with a single low energy shockwave pulse | Authors: | Kung, Yi KUAN-YU CHEN Liao, Wei-Hao Hsu, Yi-Hua CHUEH-HUNG WU MING-YEN HSIAO ABEL PO-HAO HUANG WEN-SHIANG CHEN |
Keywords: | Blood-cerebrospinal fluid barrier; Blood–brain barrier; Central nervous system; Glioblastoma multiforme; Leptomeningeal carcinomatosis; Low-energy extracorporeal focused shockwave pulse | Issue Date: | 6-Jan-2022 | Publisher: | BMC | Journal Volume: | 19 | Journal Issue: | 1 | Source: | Fluids and barriers of the CNS | Abstract: | The blood-cerebrospinal fluid (CSF) barrier (BCSFB) is critically important to the pathophysiology of the central nervous system (CNS). However, this barrier prevents the safe transmission of beneficial drugs from the blood to the CSF and thus the spinal cord and brain, limiting their effectiveness in treating a variety of CNS diseases. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/593654 | ISSN: | 2045-8118 | DOI: | 10.1186/s12987-021-00303-x |
Appears in Collections: | 醫學系 |
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