https://scholars.lib.ntu.edu.tw/handle/123456789/593923
標題: | The Expression of Non-Coding RNAs and Their Target Molecules in Rheumatoid Arthritis: A Molecular Basis for Rheumatoid Pathogenesis and Its Potential Clinical Applications | 作者: | Tsai, Chang-Youh SONG-CHOU HSIEH Liu, Chih-Wei CHENG-HSUN LU Liao, Hsien-Tzung Chen, Ming-Han KO-JEN LI CHENG-HAN WU CHIEH-YU SHEN YU-MIN KUO CHIA-LI YU |
關鍵字: | RANK-RANKL-OPG signaling; Wnt/β-catenin pathway; anti-citrullinated protein antibody; bone-marrow-derived stem cell; fibroblast-like synoviocyte; non-coding RNA; peptidylarginine deiminase; rheumatoid arthritis | 公開日期: | 26-五月-2021 | 出版社: | MDPI | 卷: | 22 | 期: | 11 | 起(迄)頁: | 5689 | 來源出版物: | International journal of molecular sciences | 摘要: | Rheumatoid arthritis (RA) is a typical autoimmune-mediated rheumatic disease presenting as a chronic synovitis in the joint. The chronic synovial inflammation is characterized by hyper-vascularity and extravasation of various immune-related cells to form lymphoid aggregates where an intimate cross-talk among innate and adaptive immune cells takes place. These interactions facilitate production of abundant proinflammatory cytokines, chemokines and growth factors for the proliferation/maturation/differentiation of B lymphocytes to become plasma cells. Finally, the autoantibodies against denatured immunoglobulin G (rheumatoid factors), EB virus nuclear antigens (EBNAs) and citrullinated protein (ACPAs) are produced to trigger the development of RA. Furthermore, it is documented that gene mutations, abnormal epigenetic regulation of peptidylarginine deiminase genes 2 and 4 (PADI2 and PADI4), and thereby the induced autoantibodies against PAD2 and PAD4 are implicated in ACPA production in RA patients. The aberrant expressions of non-coding RNAs (ncRNAs) including microRNAs (miRs) and long non-coding RNAs (lncRNAs) in the immune system undoubtedly derange the mRNA expressions of cytokines/chemokines/growth factors. In the present review, we will discuss in detail the expression of these ncRNAs and their target molecules participating in developing RA, and the potential biomarkers for the disease, its diagnosis, cardiovascular complications and therapeutic response. Finally, we propose some prospective investigations for unraveling the conundrums of rheumatoid pathogenesis. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/593923 | ISSN: | 16616596 | DOI: | 10.3390/ijms22115689 | SDG/關鍵字: | autoantibody; cyclic citrullinated peptide antibody; long untranslated RNA; microRNA; protein arginine deiminase type 2; protein arginine deiminase type 2 antibody; protein arginine deiminase type 4; protein arginine deiminase type 4 antibody; rheumatoid factor; unclassified drug; untranslated RNA; long untranslated RNA; PADI2 protein, human; PADI4 protein, human; antibody production; bone destruction; bone development; bone marrow mesenchymal stem cell; bone metabolism; cardiovascular disease; cell level; cell polarity; chronic inflammation; enzyme activity; exosome; fibroblast like synoviocyte; gene expression; human; immunopathogenesis; inflammation; interactions with RNA; macrophage; molecular interaction; nonhuman; protein expression; Review; rheumatic disease; rheumatoid arthritis; RNA blood level; synoviocyte; T lymphocyte subpopulation; biosynthesis; gene expression regulation; genetic epigenesis; genetics; metabolism; pathology; rheumatoid arthritis; Arthritis, Rheumatoid; Epigenesis, Genetic; Gene Expression Regulation, Enzymologic; Humans; Protein-Arginine Deiminase Type 2; Protein-Arginine Deiminase Type 4; RNA, Long Noncoding |
顯示於: | 醫學系 |
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