https://scholars.lib.ntu.edu.tw/handle/123456789/594147
標題: | Defining the endoscopic ultrasound features of chronic pancreatitis in Asians: A multicenter validation study | 作者: | Koh C.J. Lakhtakia S. Kida M. Lesmana C.R.A. Ang T.L. Vu C.K.F. Aye T.T. Park S.H. Almadi M.A. Chong C.C.-N. Tang R.S.Y. Wu X. Hilmi I. Dhir V. Pausawasdi N. Basha J. Jin Z.-D. Yang A.M. Teoh A.Y.B. Seo D.-W. HSIU-PO WANG Ho K.Y. |
公開日期: | 2021 | 出版社: | Georg Thieme Verlag | 卷: | 53 | 期: | 6 | 起(迄)頁: | 595-602 | 來源出版物: | Endoscopy | 摘要: | Background Although endoscopic ultrasound (EUS) features and criteria have been described in chronic pancreatitis, challenges remain with interoperator variability and ease of adoption. The aim of this study was to define and validate the EUS features of chronic pancreatitis in a multicenter prospective study in Asia. Method: The study was divided into two parts: the first part was conducted to derive the EUS features of chronic pancreatitis with adequate interoperator agreement; the second was to prospectively evaluate these features in a multicenter cross-sectional study and determine the optimal combination of features for the diagnosis of chronic pancreatitis. Prospectively enrolled cases had standard internationally validated radiologic or histologic features of chronic pancreatitis, and controls were patients without chronic pancreatitis who underwent EUS examination. Results: The top six EUS features that had good interobserver agreement (mean kappa 0.73, range 0.60-0.90) were selected to be further evaluated in part II of the study. These included: hyperechoic foci with shadowing, lobularity with honeycombing, cysts, dilated main pancreatic duct, dilated side branches, and calculi in the main pancreatic duct. A total of 284 subjects (132 cases, 152 controls) were enrolled from 12 centers in Asia. All six features had high accuracy ranging from 63.3% to 89.1%. Two or more of these six EUS features accurately defined chronic pancreatitis (sensitivity 94.7%, specificity 98.0%), with an area under the receiver operating curve of 0.986. Conclusion: This multicenter Asian study characterized and defined the EUS features of chronic pancreatitis. This provides a useful tool in clinical practice and further research in pancreatic cancer surveillance. ? 2021 Royal Society of Chemistry. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85092690649&doi=10.1055%2fa-1217-3112&partnerID=40&md5=2d565d4525178660d0cefede7026b2eb https://scholars.lib.ntu.edu.tw/handle/123456789/594147 |
ISSN: | 0013-726X | DOI: | 10.1055/a-1217-3112 | SDG/關鍵字: | adult; area under the curve; Article; Asian; chronic pancreatitis; clinical feature; cross-sectional study; diagnostic accuracy; diagnostic test accuracy study; endoscopic retrograde cholangiopancreatography; endoscopic ultrasonography; female; histology; human; interrater reliability; magnetic resonance cholangiopancreatography; major clinical study; male; multicenter study; nuclear magnetic resonance imaging; pancreatic duct; pancreatography; predictive value; prevalence; priority journal; prospective study; sensitivity and specificity; standard; stone formation; validation study; videorecording; x-ray computed tomography; Asia; Asian continental ancestry group; chronic pancreatitis; clinical trial; diagnostic imaging; endoscopic ultrasonography; Asia; Asian Continental Ancestry Group; Cross-Sectional Studies; Endosonography; Humans; Pancreatitis, Chronic; Prospective Studies; Sensitivity and Specificity |
顯示於: | 醫學系 |
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