https://scholars.lib.ntu.edu.tw/handle/123456789/594452
標題: | New Trichothecenes Isolated from the Marine Algicolous Fungus Trichoderma brevicompactum | 作者: | Safwan, Safwan Wang, Shih Wei Hsiao, George Hsiao, Sui Wen Hsu, Su Jung TZONG-HUEI LEE Lee, Ching Kuo |
關鍵字: | Cytotoxic activities | Endophytic fungus | Marine alga | Trichoderma brevicompactum | Trichothecenes;Cytotoxic activities; Endophytic fungus; Marine alga; Trichoderma brevicompactum; Trichothecenes | 公開日期: | 1-二月-2022 | 出版社: | MDPI | 卷: | 20 | 期: | 2 | 起(迄)頁: | Article number 80 | 來源出版物: | Marine Drugs | 摘要: | Eight trichothecenes, including four new compounds 1–4 and four known entities 5–8, together with one known cyclonerane (9) were isolated from the solid-state fermentation of Trichoderma brevicompactum NTU439 isolated from the marine alga Mastophora rosea. The structures of 1–9 were determined by 1D/2D NMR (nuclear magnetic resonance), MS (mass spectrometry), and IR (infrared spectroscopy) spectroscopic data. All of the compounds were evaluated for cytotoxic activity against HCT-116, PC-3, and SK-Hep-1 cancer cells by the SRB assay, and compound 8 showed promising cytotoxic activity against all three cancer cell lines with the IC50 values of 3.3 ± 0.3, 5.3 ± 0.3, and 1.8 ± 0.8 µM, respectively. Compounds 1–2, 4–6, and 7–8 potently inhibited LPS-induced NO production, and compounds 5 and 8 showed markedly inhibited gelatinolysis of MMP-9 in S1 protein-stimulated THP-1 monocytes. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/594452 | ISSN: | 16603397 | DOI: | 10.3390/md20020080 | SDG/關鍵字: | gelatinase B; lipopolysaccharide; nitric oxide; sulforhodamine B; trichothecene derivative; antineoplastic activity; Article; cell assay; cell mediated cytotoxicity; chemical structure; controlled study; drug isolation; gelatinization; HCT 116 cell line; |
顯示於: | 漁業科學研究所 |
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