|Title:||New Trichothecenes Isolated from the Marine Algicolous Fungus Trichoderma brevicompactum||Authors:||Safwan, Safwan
Wang, Shih Wei
Hsiao, Sui Wen
Hsu, Su Jung
Lee, Ching Kuo
|Keywords:||Cytotoxic activities | Endophytic fungus | Marine alga | Trichoderma brevicompactum | Trichothecenes;Cytotoxic activities; Endophytic fungus; Marine alga; Trichoderma brevicompactum; Trichothecenes||Issue Date:||1-Feb-2022||Publisher:||MDPI||Journal Volume:||20||Journal Issue:||2||Start page/Pages:||Article number 80||Source:||Marine Drugs||Abstract:||
Eight trichothecenes, including four new compounds 1–4 and four known entities 5–8, together with one known cyclonerane (9) were isolated from the solid-state fermentation of Trichoderma brevicompactum NTU439 isolated from the marine alga Mastophora rosea. The structures of 1–9 were determined by 1D/2D NMR (nuclear magnetic resonance), MS (mass spectrometry), and IR (infrared spectroscopy) spectroscopic data. All of the compounds were evaluated for cytotoxic activity against HCT-116, PC-3, and SK-Hep-1 cancer cells by the SRB assay, and compound 8 showed promising cytotoxic activity against all three cancer cell lines with the IC50 values of 3.3 ± 0.3, 5.3 ± 0.3, and 1.8 ± 0.8 µM, respectively. Compounds 1–2, 4–6, and 7–8 potently inhibited LPS-induced NO production, and compounds 5 and 8 showed markedly inhibited gelatinolysis of MMP-9 in S1 protein-stimulated THP-1 monocytes.
|URI:||https://scholars.lib.ntu.edu.tw/handle/123456789/594452||ISSN:||16603397||DOI:||10.3390/md20020080||SDG/Keyword:||gelatinase B; lipopolysaccharide; nitric oxide; sulforhodamine B; trichothecene derivative; antineoplastic activity; Article; cell assay; cell mediated cytotoxicity; chemical structure; controlled study; drug isolation; gelatinization; HCT 116 cell line;
|Appears in Collections:||漁業科學研究所|
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