https://scholars.lib.ntu.edu.tw/handle/123456789/595746
標題: | Prognostic indicators for the onset of ischaemic versus haemorrhagic stroke in stable coronary artery disease | 作者: | Wang, Wei-Ting Wu, Tao-Cheng Tseng, Wei-Kung YEN-WEN WU Lin, Tsung-Hsien Yeh, Hung-I Chang, Kuan-Cheng Wang, Ji-Hung Leu, Hsin-Bang Yin, Wei-Hsian CHAU-CHUNG WU Chen, Jaw-Wen |
關鍵字: | coronary artery disease; haemorrhagic stroke; ischaemic stroke; low-density lipoprotein cholesterol; myeloperoxidase; statins; INTRACEREBRAL HEMORRHAGE; VASCULAR EVENTS; CASE-FATALITY; MORTALITY; RISK; POPULATION; ASSOCIATION; MECHANISMS; SEVERITY | 公開日期: | 3-十二月-2021 | 出版社: | LIPPINCOTT WILLIAMS & WILKINS | 卷: | 100 | 期: | 48 | 來源出版物: | Medicine | 摘要: | The incidence of stroke may be increased in patients with coronary artery disease (CAD). We aimed to investigate the specific risk factors for the development of ischaemic and haemorrhagic stroke in stable CAD patients.Patients with stable CAD were prospectively enrolled for future cardiovascular events in Taiwan. All the patients had received coronary interventions and were stable for least 1 month before enrolment. The incidence of ischaemic stroke was identified and confirmed by telephone and hospital records. Baseline characteristics, including demographic data, lipid profiles, medications, and biomarkers for potential inflammatory and atherosclerosis, were analysed.In total, 1428 patients (age, 63.07 ± 11.4 years; 1207 males) were under standard medical treatment and regularly followed-up for at least 4 years. Multivariate logistic regression analysis showed that baseline serum myeloperoxidase (MPO) level (hazard ratio [HR]: 1.89, 95% CI: 1.16-3.10, P = .01) and statin use (HR: 0.37; 95% CI: 0.17-0.79, P = .01) were independently associated with the onset of ischaemic stroke. Age (HR: 1.07, 95% CI: 1.00-1.14, P = .04) and angiotensin receptor blocker (ARB) use (HR: 0.37, 95% CI: 0.17-0.79, P = .01) were independently associated with future onset of intracranial haemorrhage (ICH), implying the different mechanisms of ischaemic stroke and ICH.Age and ARB use were related to ICH onset. Baseline MPO level and statin use were independently associated with longer and shorter future ischaemic stroke onset in stable CAD patients, respectively. Further studies are indicated to confirm the potential mechanisms and advance individual risk stratification for the onset of different types of stroke in clinical CAD. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/595746 | ISSN: | 0025-7974 1536-5964 |
DOI: | 10.1097/MD.0000000000027973 | SDG/關鍵字: | 1 alkyl 2 acetylglycerophosphocholine esterase; amino terminal pro brain natriuretic peptide; angiotensin receptor antagonist; creatinine; CXCL16 chemokine; dipeptidyl carboxypeptidase inhibitor; fatty acid binding protein 3; hemoglobin; high density lipoprotein cholesterol; myeloperoxidase; neutrophil gelatinase associated lipocalin; triacylglycerol; adult; Article; atherosclerosis; brain hemorrhage; controlled study; coronary artery disease; coronary risk; demography; electrocardiogram; female; follow up; heart infarction; human; incidence; ischemic stroke; laboratory test; major clinical study; male; medical record; middle aged; multicenter study; multivariate logistic regression analysis; observational study; percutaneous coronary intervention; prognosis; prospective study; Taiwan |
顯示於: | 醫學教育暨生醫倫理學科所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。