https://scholars.lib.ntu.edu.tw/handle/123456789/595884
標題: | A role for dopamine in C. elegans avoidance behavior induced by mitochondrial stress | 作者: | Chou, Shih Hua Chen, Yen Ju Liao, Chien Po CHUN-LIANG PAN |
關鍵字: | Aversive learning | Avoidance behavior | C. elegans | Dopamine | Mitochondria | Neural circuit | Stress | 公開日期: | 1-一月-2022 | 來源出版物: | Neuroscience Research | 摘要: | Physiological stress triggers aversive learning that profoundly alters animal behavior. Systemic mitochondrial disruption induces avoidance of C. elegans to non-pathogenic food bacteria. Mutations in cat-2 and dat-1, which control dopamine synthesis and reuptake, respectively, impair this learned bacterial avoidance, suggesting that dopaminergic modulation is essential. Cell-specific rescue experiments indicate that dopamine likely acts from the CEP and ADE neurons to regulate learned bacterial avoidance. We find that mutations in multiple dopamine receptor genes, including dop-1, dop-2 and dop-3, reduced learned bacterial avoidance. Our work reveals a role for dopamine signaling in C. elegans learned avoidance behavior induced by mitochondrial stress. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/595884 | ISSN: | 01680102 | DOI: | 10.1016/j.neures.2022.01.005 |
顯示於: | 分子醫學研究所 |
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