https://scholars.lib.ntu.edu.tw/handle/123456789/596151
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Lin T.-Y. | en_US |
dc.contributor.author | Cheng Y.-C. | en_US |
dc.contributor.author | Yang H.-C. | en_US |
dc.contributor.author | WEI-CHOU LIN | en_US |
dc.contributor.author | Wang C.-C. | en_US |
dc.contributor.author | Lai P.-L. | en_US |
dc.contributor.author | Shieh S.-Y. | en_US |
dc.date.accessioned | 2022-03-04T03:48:24Z | - |
dc.date.available | 2022-03-04T03:48:24Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0950-9232 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84863718409&doi=10.1038%2fonc.2011.491&partnerID=40&md5=5e1f5339ad2bfc57951d59d1e48f99cc | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/596151 | - |
dc.description.abstract | The B-cell translocation gene 3 (BTG3) is a member of the antiproliferative BTG gene family and a downstream target of p53. BTG3 also binds and inhibits E2F1. Although it connects functionally two major growth-regulatory pathways, the physiological role of BTG3 remains largely uncharacterized. Here, we present evidence that loss of BTG3 in normal cells induced cellular senescence, which was correlated with enhanced ERK-AP1 signaling and elevated expression of the histone H3K27me3 demethylase JMJD3/KDM6B, leading to acute induction of p16 INK4a. Importantly, we also found that BTG3 expression is specifically downregulated in prostate cancer, thus providing a physiological link with human cancers. Our data suggest that BTG3 may have a fail-safe role against tumorigenic progression. ? 2012 Macmillan Publishers Limited All rights reserved. | - |
dc.relation.ispartof | Oncogene | - |
dc.subject | BTG3; cellular senescence; ERK; JMJD3/KDM6B | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | cyclin dependent kinase inhibitor 2A; histone demethylase; histone H3K27me3 demethylase; mitogen activated protein kinase; transcription factor AP 1; unclassified drug; article; B cell translocation gene 3; controlled study; DNA sequence; down regulation; fibroblast; gene expression; gene loss; human; human cell; human tissue; phenotype; priority journal; promoter region; prostate cancer; protein expression; senescence; signal transduction; transcription initiation; tumor suppressor gene; upregulation; Cell Aging; Cell Line; Cyclin-Dependent Kinase Inhibitor p16; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Humans; Jumonji Domain-Containing Histone Demethylases; Male; Prostatic Neoplasms; Proteins; Signal Transduction; Transcription Factor AP-1; Transcriptional Activation; Tumor Suppressor Proteins | - |
dc.title | Loss of the candidate tumor suppressor BTG3 triggers acute cellular senescence via the ERK-JMJD3-p16 INK4a signaling axis | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1038/onc.2011.491 | - |
dc.identifier.pmid | 22020331 | - |
dc.identifier.scopus | 2-s2.0-84863718409 | - |
dc.relation.pages | 3287-3297 | - |
dc.relation.journalvolume | 31 | - |
dc.relation.journalissue | 27 | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Pathology-NTUH | - |
crisitem.author.orcid | 0000-0003-2857-3479 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 病理學科所 |
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