https://scholars.lib.ntu.edu.tw/handle/123456789/596430
標題: | Diabetes impairs recovery from noise-induced temporary hearing loss | 作者: | Wu H.-P. TSUN-JEN CHENG CHING-TING TAN Yue Leon Guo Hsu C.-J. |
關鍵字: | Auditory brainstem response; Diabetes; Distortion product otoacoustic emission; Noise-induced hearing loss; Temporary threshold shift | 公開日期: | 2009 | 卷: | 119 | 期: | 6 | 起(迄)頁: | 1190-1194 | 來源出版物: | Laryngoscope | 摘要: | Objectives/Hypothesis: The purpose of this study is to investigate whether diabetes impairs the recovery from noised-induced temporary hearing loss. Methods: Twenty-eight male Wistar rats were divided into three groups: control, diabetes with insulin control (DI), and diabetes without insulin control (DM). Diabetes was induced by intraperitoneal injection of streptozotocin. All animals were exposed to white noise at 110 dB SPL for 8 hours. Auditory brainstem response (ABR) thresholds and distortion product otoacoustic emission (DPOAE) amplitudes were measured for all animals 1 day prior to noise exposure to obtain a baseline for hearing function, and then 1 hour, 1 day, 2 days, 4 days, 7 days, and 14 days after noise exposure. Results: One hour post exposure, ABR thresholds shifted markedly, and DPOAE was reduced similarly in all groups. Both ABR thresholds and DPOAE returned to the baseline in the control group at day 1, but they were not back to the baseline in the DM group even by day 14. Compared with the control group, the ABR threshold shifts and DPOAE returned to baseline more slowly in the DI group. Conclusions: The present study suggests that diabetic patients need proper blood sugar control and probably need more effective preventive measures to preserve their hearing from the effects of noise. ? 2009 The American Laryngological, Rhinological and Otological Society, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-66849093295&doi=10.1002%2flary.20221&partnerID=40&md5=c4654d9630eedb1159a1ef496abc1472 https://scholars.lib.ntu.edu.tw/handle/123456789/596430 |
ISSN: | 0023-852X | DOI: | 10.1002/lary.20221 | SDG/關鍵字: | isophane insulin; streptozocin; amplitude modulation; animal experiment; article; control group; controlled study; diabetes mellitus; evoked brain stem auditory response; glucose blood level; hearing; hearing loss; male; noise; nonhuman; otoacoustic emission; priority journal; rat; streptozocin diabetes; Wistar rat; animal; auditory threshold; brain stem; experimental diabetes mellitus; metabolism; noise; pathophysiology; physiology; spontaneous otoacoustic emission; Animals; Auditory Fatigue; Blood Glucose; Brain Stem; Diabetes Mellitus, Experimental; Evoked Potentials, Auditory, Brain Stem; Male; Noise; Otoacoustic Emissions, Spontaneous; Rats; Rats, Wistar |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。