https://scholars.lib.ntu.edu.tw/handle/123456789/596525
標題: | Pre-treatment urea breath test results predict the efficacy of Helicobacter pylori eradication therapy in patients with active duodenal ulcers | 作者: | Lai Y.-C. JYH-CHIN YANG Huang S.-H. |
公開日期: | 2004 | 出版社: | Baishideng Publishing Group Co | 卷: | 10 | 期: | 7 | 起(迄)頁: | 991-994 | 來源出版物: | World Journal of Gastroenterology | 摘要: | Aim: To evaluate the association of pre-treatment 13C-urea breath test (UBT) results with H pylori density and efficacy of eradication therapy in patients with active duodenal ulcers. Methods: One hundred and seventeen consecutive outpatients with active duodenal ulcer and H pylori infection were recruited. H pylori density was histologically graded according to the Sydney system. Each patient received lansoprazole (30 mg b.i.d.), clarithromycin (500 mg b.i.d.) and amoxicillin (1 g b.i.d.) for 1 week. According to pre-treatment UBT values, patients were allocated into low (<16?), intermediate (16-35?), and high (>35?) UBT groups. Results: A significant correlation was found between pre-treatment UBT results and H pylori density (P<0.001). H pylori eradication rates were 94.9%, 94.4% and 81.6% in the low, intermediate and high UBT groups, respectively (per protocol analysis, P=0.11). When patients were assigned into two groups (UBT results ?35? and >35?), the eradication rates were 94.7% and 81.6%, respectively (P=0.04). Conclusion: The intragastric bacterial load of H pylori can be evaluated by UBT, and high pre-treatment UBT results can predict an adverse outcome of eradication therapy. Copyright ? 2004 by The WJG Press. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-1842686777&doi=10.3748%2fwjg.v10.i7.991&partnerID=40&md5=cd98ac1f9a821f0fdd27dd7f4710eb0d https://scholars.lib.ntu.edu.tw/handle/123456789/596525 |
ISSN: | 1007-9327 | DOI: | 10.3748/wjg.v10.i7.991 | SDG/關鍵字: | amoxicillin; antacid agent; bismuth; carbon 13; clarithromycin; lansoprazole; nonsteroid antiinflammatory agent; stomach secretion inhibitor; adult; article; bacterial cell; cell density; clinical protocol; controlled study; correlation analysis; disease activity; drug efficacy; duodenum ulcer; eradication therapy; female; Helicobacter infection; Helicobacter pylori; human; major clinical study; male; outcomes research; outpatient; patient coding; prediction; urea breath test |
顯示於: | 醫學系 |
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