https://scholars.lib.ntu.edu.tw/handle/123456789/596601
標題: | A CMOS-based poly-silicon sub-micron wire biosensor for multiple biomarker detections in clinical samples | 作者: | Wang, I.-S. JEN-KUANG LEE Lin, H.-H. Sun, Y.-H. Chen, G.-Y. CHIH-TING LIN |
公開日期: | 2015 | 出版社: | Institute of Electrical and Electronics Engineers Inc. | 起(迄)頁: | 1657-1660 | 來源出版物: | 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 | 摘要: | This paper reports an integrated poly-silicon sub-micron wire biosensor for multiple biomarker detections in clinical samples. It is fabricated by a commercialized 0.35μm CMOS process node. For the first time, an integrated CMOS biosensor chip is experimentally validated in human whole blood and plasma. In this work, a series of anemia/diabetes biomarkers, such as low-density lipoprotein (LDL), hemoglobin (Hb), glycated hemoglobin (HbA1c), and ferritin are examined by the developed CMOS poly-silicon biosensors. The experimental results successfully indicate differences of biomarker concentrations between sick and healthy people. As a consequence, this work demonstrates a potential of CMOS applications in clinical biomarker detections for point-of-care technology. ? 2015 IEEE. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84955517122&doi=10.1109%2fTRANSDUCERS.2015.7181260&partnerID=40&md5=40ede5a806c9fde4f3184fe74d03a21a https://scholars.lib.ntu.edu.tw/handle/123456789/596601 |
ISSN: | #VALUE! | DOI: | 10.1109/TRANSDUCERS.2015.7181260 | SDG/關鍵字: | Actuators; Biosensors; CMOS integrated circuits; Hemoglobin; Microsystems; Polysilicon; Silicon; Solid-state sensors; Transducers; Wire; Clinical biomarkers; Clinical samples; CMOS biosensors; Field effects; Glycated hemoglobin (HbA1c); Low density lipoproteins; Multiple biomarkers; Sub-micron wires; Biomarkers |
顯示於: | 醫學系 |
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