https://scholars.lib.ntu.edu.tw/handle/123456789/596936
標題: | Prognostic impact of allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia patients with internal tandem duplication of FLT3 | 作者: | PO-HAN LIN Lin C.-C. Yang H.-I. Li L.-Y. Bai L.-Y. Chiu C.-F. Liao Y.-M. Lin C.-Y. Hsieh C.-Y. Lin C.-Y. Ho C.-M. Yang S.-F. Peng C.-T. Tsai F.-J. Yeh S.-P. |
關鍵字: | Acute myeloid leukemia; Allogeneic hematopoietic stem cell transplantation; FLT3 | 公開日期: | 2013 | 卷: | 37 | 期: | 3 | 起(迄)頁: | 287-292 | 來源出版物: | Leukemia Research | 摘要: | The FLT3 gene with internal tandem duplication (ITD) is a poor prognostic factor in patients with acute myeloid leukemia (AML), and the efficacy of allogeneic hematopoietic stem cell transplantation (HSCT) for AML patients with FLT3-ITD is controversial. We examined 122 AML patients; 34 patients had FLT3-ITD and 39 patients received allogeneic HSCT. The median overall survival (OS) of patients with wt. FLT3/nonHSCT, wt. FLT3/HSCT, FLT3-ITD/nonHSCT and FLT3-ITD/HSCT was 40.7 months, 53.4 months, 9.8 months and not reached, respectively (p=0.006). Compared to the wt. FLT3/nonHSCT patients, the hazard ratio (95% CI) of OS for wt. FLT3/HSCT, FLT3-ITD/nonHSCT and FLT3-ITD/HSCT was 1.39 (0.61-3.18), 3.57 (1.58-8.10) and 0.40 (0.11-1.59), respectively, after adjustment of age, sex, WBC, LDH, karyotype, NPM, and FAB classification. This result indicated that patients with FLT3-ITD/nonHSCT had a significantly worse outcome, but allogeneic HSCT improved the prognosis for patients with FLT3-ITD. ? 2012 Elsevier Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84872932688&doi=10.1016%2fj.leukres.2012.10.005&partnerID=40&md5=e0523545c36ed9cbb7e1b518cec07f46 https://scholars.lib.ntu.edu.tw/handle/123456789/596936 |
ISSN: | 0145-2126 | DOI: | 10.1016/j.leukres.2012.10.005 | SDG/關鍵字: | aciclovir; anthracycline; busulfan; CD135 antigen; ciprofloxacin; cotrimoxazole; cyclophosphamide; cyclosporin; cytarabine; etoposide; fluconazole; fludarabine; granulocyte colony stimulating factor; methotrexate; mitoxantrone; mycophenolic acid 2 morpholinoethyl ester; thymocyte antibody; acute granulocytic leukemia; adolescent; adult; age; aged; allogeneic hematopoietic stem cell transplantation; article; cancer recurrence; cell proliferation; cell survival; child; controlled study; disease free survival; drug megadose; female; FLT3 gene; gender; gene duplication; gene mutation; graft versus host reaction; hazard ratio; human; immunophenotyping; infection; infection prevention; internal tandem duplication; karyotype; leukocyte count; major clinical study; male; morphology; myeloablative conditioning; overall survival; priority journal; retrospective study; school child; Adolescent; Adult; Aged; Child; Female; fms-Like Tyrosine Kinase 3; Gene Duplication; Gene Expression Regulation, Neoplastic; Hematopoietic Stem Cell Transplantation; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Prognosis; Tandem Repeat Sequences; Transplantation, Homologous; Young Adult |
顯示於: | 基因體暨蛋白體醫學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。