https://scholars.lib.ntu.edu.tw/handle/123456789/597021
標題: | Increased risk of fracture and postfracture adverse events in patients with diabetes: Two nationwide population-based retrospective cohort studies | 作者: | Liao C.-C. Lin C.-S. Shih C.-C. Yeh C.-C. YI-CHENG CHANG Lee Y.-W. Chen T.-L. |
公開日期: | 2014 | 出版社: | American Diabetes Association Inc. | 卷: | 37 | 期: | 8 | 起(迄)頁: | 2246-2252 | 來源出版物: | Diabetes Care | 摘要: | OBJECTIVE: The relationship between diabetes and fracture is not completely understood. This study evaluated fracture risk and postfracture mortality in patients with diabetes. RESEARCH DESIGN AND METHODS: We identified 32,471 adults newly diagnosed with diabetes in 2000-2003 using Taiwan's National Health Insurance Research Database. A comparison cohort of 64,942 adults without diabetes was randomly selected from the same dataset, with frequency matched by age and sex. Fracture events in 2000-2008 were ascertained from medical claims. Adjusted hazard ratios (HRs) and 95% CIs of fracture associated with diabetes were calculated. A nested cohort study of 17,002 patients with fracture receiving repair surgeries between 2004 and 2010 calculated adjusted odds ratios (ORs) and 95% CIs of adverse events after fracture in patients with and without diabetes. RESULTS: During 652,530 person-years of follow-up, there were 12,772 newly diagnosed fracture cases. The incidences of fracture for people with diabetes and without were 24.2 and 17.1 per 1,000 person-years, respectively (P < 0.0001). Compared with people without diabetes, the adjusted HR of fracture was 1.66 (95% CI 1.60-1.72) for people with diabetes. The ORs of postfracture deep wound infection, septicemia, and mortality associated with diabetes were 1.34 (95% CI 1.06-1.71), 1.42 (95% CI 1.23-1.64), and 1.27 (95% CI 1.02-1.60), respectively. CONCLUSIONS: Diabetes was associated with fracture. Patients with diabetes had more adverse events and subsequent mortality after fracture. Prevention of fracture and postfracture adverse events is needed in this susceptible population. ? 2014 by the American Diabetes Association. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84904994755&doi=10.2337%2fdc13-2957&partnerID=40&md5=02e1d4db3e02d985cf6968aad3c87409 https://scholars.lib.ntu.edu.tw/handle/123456789/597021 |
ISSN: | 0149-5992 | DOI: | 10.2337/dc13-2957 | SDG/關鍵字: | adult; age distribution; aged; article; cohort analysis; comorbidity; controlled study; diabetes mellitus; disease association; disease predisposition; female; follow up; fracture; human; incidence; longitudinal study; lowest income group; major clinical study; male; mortality; osteoporosis; population research; randomized controlled trial; retrospective study; risk assessment; risk factor; septicemia; sex difference; urbanization; wound infection; complication; Diabetes Complications; diabetes mellitus; Fractures, Bone; middle aged; Taiwan; very elderly; young adult; Adult; Aged; Aged, 80 and over; Cohort Studies; Diabetes Complications; Diabetes Mellitus; Female; Fractures, Bone; Humans; Incidence; Male; Middle Aged; Retrospective Studies; Risk Factors; Taiwan; Young Adult |
顯示於: | 基因體暨蛋白體醫學研究所 |
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