https://scholars.lib.ntu.edu.tw/handle/123456789/598174
標題: | Hydrogen Bond Strength-Mediated Self-Assembly of Supramolecular Nanogels for Selective and Effective Cancer Treatment | 作者: | Ilhami F.B Yang Y.-T Lee A.-W Chiao Y.-H Chen J.-K Lee D.-J Lai J.-Y Cheng C.-C. DUU-JONG LEE |
關鍵字: | Bond strength (materials);Cell death;Controlled drug delivery;Cytotoxicity;Diseases;Hydrogen bonds;Nanostructured materials;Polyethylenes;Self assembly;Stability;Supramolecular chemistry;Cancer cells;Cancer therapy;Delivery performance;Hydrogen bond strength;Nanocarriers;Nanogels;Physical characteristics;Quadruple hydrogen bonding;Supramolecular polymers;Telechelic polymers;Polyethylene glycols;cytosine;dimer;doxorubicin;hydrogen;macrogol;nanocarrier;nanogel;polymer;drug carrier;apoptosis;aqueous solution;Article;cancer cell;cancer therapy;catalysis;chemical interaction;controlled study;cytotoxicity;drug delivery system;encapsulation;female;flow cytometry;fluorescence intensity;HeLa cell line;human;human cell;hydrodynamics;hydrogen bond;hydrophilicity;hydrophobicity;in vitro study;incubation time;internalization (cell);matrix assisted laser desorption ionization time of flight mass spectrometry;Michael addition;molecular weight;MTT assay;NIH 3T3 cell line;particle size;pH;quantitative analysis;release assay;scanning electron microscopy;spectrofluorometry;sustained drug release;synthesis;zeta potential;micelle;neoplasm;Drug Carriers;Humans;Hydrogen;Hydrogen Bonding;Micelles;Neoplasms;Polyethylene Glycols | 公開日期: | 2021 | 卷: | 22 | 期: | 10 | 起(迄)頁: | 4446-4457 | 來源出版物: | Biomacromolecules | 摘要: | This study provides a significant contribution to the development of multiple hydrogen-bonded supramolecular nanocarrier systems by demonstrating that controlling the hydrogen bond strength within supramolecular polymers represents a crucial factor to tailor the drug delivery performance and enhance the effectiveness of cancer therapy. Herein, we successfully developed two kinds of poly(ethylene glycol)-based telechelic polymers Cy-PEG and UrCy-PEG having self-constituted double and quadruple hydrogen-bonding cytosine (Cy) and ureido-cytosine (UrCy) end-capped groups, respectively, which directly assemble into spherical nanogels with a number of interesting physical characteristics in aqueous solutions. The UrCy-PEG nanogels containing quadruple hydrogen-bonded UrCy dimers exhibited excellent long-term structural stability in a serum-containing biological medium, whereas the double hydrogen-bonded Cy moieties could not maintain the structural integrity of the Cy-PEG nanogels. More importantly, after the drug encapsulation process, a series of in vitro experiments clearly confirmed that drug-loaded UrCy-PEG nanogels induced selective apoptotic cell death in cancer cells without causing significant cytotoxicity to healthy cells, while drug-loaded Cy-PEG nanogels exerted nonselective cytotoxicity toward both cancer and normal cells, indicating that increasing the strength of hydrogen bonds in nanogels plays a key role in enhancing the selective cellular uptake and cytotoxicity of drugs and the subsequent induction of apoptosis in cancer cells. ? 2021 American Chemical Society. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115935571&doi=10.1021%2facs.biomac.1c01022&partnerID=40&md5=336b3183673bbdf15861f23399688828 https://scholars.lib.ntu.edu.tw/handle/123456789/598174 |
ISSN: | 15257797 | DOI: | 10.1021/acs.biomac.1c01022 |
顯示於: | 化學工程學系 |
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