https://scholars.lib.ntu.edu.tw/handle/123456789/598670
標題: | Interactions of chemical components in ambient PM2.5 with influenza viruses | 作者: | Hsiao T.-C Cheng P.-C Chi K.H Wang H.-Y Pan S.-Y Kao C Lee Y.-L Kuo H.-P Chung K.F Chuang H.-C. TA-CHIH HSIAO |
關鍵字: | Air pollution;Metal;Particulate matter;Polycyclic aromatic hydrocarbon;Respiratory system;Carbon black;Polycyclic aromatic hydrocarbons;Viruses;Alveolar epitheliums;Ambients;Chemical component;Influenza A;Influenza A virus;Influenza virus;Particulate Matter;PM 2.5;Transmission mode;Virus infection;Particles (particulate matter);2 methylnaphthalene;acenaphthene;acenaphthylene;aluminum;antimony;arsenic;benzo[a]pyrene;benzo[b]fluoranthene;benzo[e]pyrene;benzo[k]fluoranthene;benz[a]anthracene;cadmium;carbon;chromium;chrysene;cobalt;complementary DNA;copper;dichloromethane;fluorene;iron;lead;manganese;metal;molybdenum;naphthalene;nickel;perylene;phenanthrene;polycyclic aromatic hydrocarbon;thallium;tin;vanadium;zinc;hydrogen peroxide;avian influenza;detection method;infectious disease;influenza;particulate matter;spatiotemporal analysis;airborne transmission;ambient air;Article;atmospheric deposition;chemical interaction;controlled study;human;influenza A;Influenza A virus (H5N1);influenza B;Influenza B virus;lower respiratory tract infection;lung alveolus epithelium;mass fragmentography;nonhuman;particulate matter 2.5;plasmid;real time reverse transcription polymerase chain reaction;RNA extraction;Soxhlet extraction;Taiwan;upper respiratory tract infection;virus detection;air pollutant;Orthomyxoviridae;Taipei;Air Pollutants;Humans;Hydrogen Peroxide | 公開日期: | 2022 | 卷: | 423 | 來源出版物: | Journal of Hazardous Materials | 摘要: | The significance of this work is that ambient PM2.5 is a direct transmission mode for influenza virus infection to the human alveolar epithelium. The concentration of PM2.5 was 11.7 ± 5.5 μg/m3 in Taipei during 24 December 2019–13 January 2020. Approximately 79% of inhaled PM2.5 is able to reach the upper-to-lower airway, and 47% of PM2.5 is able to reach the alveolar epithelium for influenza virus infection. Influenza A and B viruses were detected in PM2.5 on 9 days, and the influenza A/H5 virus was detected on 15 days during the study period. FL and Pyr were negatively correlated with the influenza A virus. D(ah)P and Acp were positively correlated with the influenza B and A/H5 viruses, respectively. Cd, V, and Zn were positively correlated with the influenza A, B, and A/H5 viruses, respectively. Next, influenza A, B, and A/H5 viral plasmids interacted with carbon black, H2O2, DEPs, and UD. We observed that H2O2 significantly decreased levels of complementary DNA of the three influenza viruses. DEPs and UD significantly decreased influenza A and A/H5 viral levels. In conclusion, chemicals in PM2.5 may play vital roles in terms of viable influenza virus in the atmosphere. ? 2021 Elsevier B.V. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115641521&doi=10.1016%2fj.jhazmat.2021.127243&partnerID=40&md5=4002c88c5b6e10fca14b30c50090de9e https://scholars.lib.ntu.edu.tw/handle/123456789/598670 |
ISSN: | 03043894 | DOI: | 10.1016/j.jhazmat.2021.127243 |
顯示於: | 環境工程學研究所 |
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