https://scholars.lib.ntu.edu.tw/handle/123456789/599020
標題: | Design Strategy for a Hydroxide-Triggered pH-Responsive Hydrogel as a Mucoadhesive Barrier to Prevent Metabolism Disorders | 作者: | Tang R.-C Chen T.-C Lin F.-H. Lin, Feng-Huei |
關鍵字: | hydrogel;hydroxide;intestine;metabolism disorders;pectin;pH-responsive;Metabolism;Nutrients;'current;Design strategies;Hydroxide;Intestine;Mucoadhesives;Nutrient transport;Nutrient uptake;Pectin;PH-responsive;pH-responsive hydrogels;Hydrogels | 公開日期: | 2021 | 卷: | 13 | 期: | 49 | 起(迄)頁: | 58340-58351 | 來源出版物: | ACS Applied Materials and Interfaces | 摘要: | Excess nutrient uptake is one of the main factors of complications related to metabolism disorders. Therefore, efforts have emerged to modulate nutrient transport in the intestine. However, current approaches are mainly invasive interventions with various side effects. Here, a pH-responsive hydrogel is formulated by acidifying the hydroxide compounds within sucralfate to allow electrostatic interactions between pectin and aluminum ions. The pH responsiveness relies on the alternation of cations and hydroxide species, providing reversible shifting from a hydrogel to a complex coacervate system. It acts as a transient physical barrier coating to inhibit intestinal absorption and changes the viscosity and barrier function in different parts of the gastrointestinal tract, showing enhanced mucoadhesive properties. The therapeutic hydrogel remarkably lowers the immediate blood glucose response by modulating nutrient contact with bowel mucosa, suggesting potential in treating diabetes. In addition, it significantly reduces weight gain, fat accumulation, and hepatic lipid deposition in rodent models. This study provides a novel strategy for fabricating pH-responsive hydrogels, which may serve as a competent candidate for metabolism disorder management. ? |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121031598&doi=10.1021%2facsami.1c17706&partnerID=40&md5=c84c1d228307d2997d2a3c6614818ba4 https://scholars.lib.ntu.edu.tw/handle/123456789/599020 |
ISSN: | 19448244 | DOI: | 10.1021/acsami.1c17706 |
顯示於: | 醫學工程學研究所 |
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