https://scholars.lib.ntu.edu.tw/handle/123456789/600409
Title: | Poly(glycerol sebacate)-co-poly(ethylene glycol)/Gelatin Hybrid Hydrogels as Biocompatible Biomaterials for Cell Proliferation and Spreading | Authors: | Chang C.-W YI-CHEUN YEH |
Keywords: | cell proliferation;cell spreading;hybrid hydrogel;poly(glycerol sebacate);thiol-ene photochemistry;Aliphatic compounds;Biocompatibility;Biomechanics;Cell culture;Cell proliferation;Cells;Crosslinking;Drug delivery;Functional polymers;Glycerol;Hydrogels;Medical applications;Polyethylene glycols;Pore size;Tissue;Tissue engineering;Biomedical applications;Cell encapsulations;Desirable features;Hybrid hydrogels;Photo crosslinking reaction;Polies (glycerolsebacate);Synthetic polymers;Tissue engineering applications;Cell engineering | Issue Date: | 2021 | Journal Volume: | 21 | Journal Issue: | 12 | Source: | Macromolecular Bioscience | Abstract: | Synthetic polymers have been widely employed to prepare hydrogels for biomedical applications, such as cell culture, drug delivery, and tissue engineering. However, the activity of cells cultured in the synthetic polymer-based hydrogels faces the challenges of limited cell proliferation and spreading compared to cells cultured in natural polymer-based hydrogels. To address this concern, a hybrid hydrogel strategy is demonstrated by incorporating thiolated gelatin (GS) into the norbornene-functionalized poly (glycerol sebacate)-co-polyethylene glycol (Nor_PGS-co-PEG, NPP) network to prepare highly biocompatible NPP/GS_UV hydrogels after the thiol-ene photo-crosslinking reaction. The GS introduces several desirable features (i.e., enhanced water content, enlarged pore size, increased mechanical property, and more cell?adhesion sites) to the NPP/GS_UV hydrogels, facilitating the cell proliferation and spreading inside the network. Thus, the highly biocompatible NPP/GS_UV hydrogels are promising materials for cell encapsulation and tissue engineering applications. Taken together, the hybrid hydrogel strategy is demonstrated as a powerful approach to fabricate hydrogels with a highly friendly environment for cell culture, expanding the biomedical applications of hydrogels. ? 2021 Wiley-VCH GmbH |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114730106&doi=10.1002%2fmabi.202100248&partnerID=40&md5=f8240b24e9ac2fa88d5023b9f7d92eb9 https://scholars.lib.ntu.edu.tw/handle/123456789/600409 |
ISSN: | 16165187 | DOI: | 10.1002/mabi.202100248 |
Appears in Collections: | 高分子科學與工程學研究所 |
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