https://scholars.lib.ntu.edu.tw/handle/123456789/600418
標題: | Engineering nanocomposite hydrogels using dynamic bonds | 作者: | Lu C.-H Yu C.-H YI-CHEUN YEH |
關鍵字: | Dynamic bonds;Nanocomposite hydrogels;Self-healing;Stimuli-responsiveness;Drug delivery;Functional polymers;Hydrogen bonds;Medical applications;Nanocomposites;Self-healing materials;Tissue engineering;Biomedical applications;Dynamic bond;Property;Schiff-base;Stimuli responsiveness;Structures and properties;Synthesised;Tissues engineerings;Hydrogels;nanohydrogel;polymer;biomaterial;nanocomposite;covalent bond;cross linking;engineering;hydrogen bond;nonhuman;Review;synergistic effect;hydrogel;Biocompatible Materials;Nanogels;Polymers | 公開日期: | 2021 | 卷: | 130 | 起(迄)頁: | 66-79 | 來源出版物: | Acta Biomaterialia | 摘要: | Nanocomposite (NC) hydrogels are promising biomaterials that possess versatile properties and functions for biomedical applications such as drug delivery, biosensor development, imaging and tissue engineering. Different strategies and chemistries have been utilized to define the structure and properties of NC hydrogels. In this review, we discuss NC hydrogels synthesized using dynamic bonds, including dynamic covalent bonds (e.g., Schiff base and boronate ester bond) and non-covalent bonds (e.g., hydrogen bonds and metal-ligand coordination). Dynamic bonds can reversibly break and reform to provide self-healing properties to NC hydrogels as well as be influenced by external factors to allow NC hydrogels with stimulus-responsiveness. The presence of dynamic bonds in NC hydrogels can occur at the polymer-polymer or polymer-particle interfaces, which also determines whether the particles act as fillers or crosslinkers in hydrogels. Several representative examples of NC hydrogels fabricated using dynamic bonds are discussed here, focusing on their design, preparation, properties, applications and future prospects. Statement of significance: This review provides an overview of the current progress in NC hydrogel development using dynamic bonds, summarizing the material design, fabrication approaches, unique performance and promising biomedical applications. The presence of both nanoparticles and dynamic bonds in hydrogels shows a combined or synergistic effect to provide hydrogels with dynamic features, definable properties, multi-functionality and stimulus-responsiveness for advanced applications. We believe that this review will be of interest to the hydrogel community and inspire researchers to develop next-generation hydrogels. ? 2021 |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109093644&doi=10.1016%2fj.actbio.2021.05.055&partnerID=40&md5=36e0f2ac8de4a8f9d96f2f4117f196b8 https://scholars.lib.ntu.edu.tw/handle/123456789/600418 |
ISSN: | 17427061 | DOI: | 10.1016/j.actbio.2021.05.055 |
顯示於: | 高分子科學與工程學研究所 |
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