https://scholars.lib.ntu.edu.tw/handle/123456789/601741
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Hsiu-Chin Huang | en_US |
dc.contributor.author | Hsiao-Yu Chen | en_US |
dc.contributor.author | CHIA-YANG CHEN | en_US |
dc.contributor.author | TANG-LONG SHEN | en_US |
dc.contributor.author | JOHN HUANG | en_US |
dc.contributor.author | NENG-YU LIN | en_US |
dc.contributor.author | Shao-Yin Sum | en_US |
dc.contributor.author | Mei-Ieng Che | en_US |
dc.contributor.author | MIN-CHUAN HUANG | en_US |
dc.date.accessioned | 2022-03-23T07:30:15Z | - |
dc.date.available | 2022-03-23T07:30:15Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0145-8884 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-41249083375&doi=10.1111%2fj.1745-4514.2008.00152.x&partnerID=40&md5=cc8edf37ca2bbc820c50990398a714ab | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/601741 | - |
dc.description.abstract | In this study, the effects of ammonium hydroxide extracts from black tea on colon cancer cells were analyzed. Here we showed that black tea extracts decreased the growth of SW480 and HCT116 cells in a dose-dependent manner. The increase of subG1 population indicated that the black tea extracts induced cancer cell death. In addition, cell migration and invasion were significantly inhibited by the black tea extracts. We also found that tyrosine phosphorylation of focal adhesion kinase and paxillin was decreased in these cells, suggesting that integrin signaling pathways were affected by the extracts. In addition, decreased phosphorylation of extracellular signal-regulated kinase and increased phosphorylation of p38 and c-Jun N-terminal kinase were observed, indicating that the extracts can modulate mitogen-activated protein kinase (MAPK) signaling pathways. These results suggest that the crude ammonium hydroxide extracts from black tea can significantly inhibit malignant phenotypes of colon cancer cells and that integrin and MAPK signaling pathways could be involved. © 2008, Blackwell Publishing. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Journal of Food Biochemistry | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.title | Ammonium hydroxide extracts from black tea inhibit growth, migration and invasion of colon cancer cells | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1111/j.1745-4514.2008.00152.x | - |
dc.identifier.scopus | 2-s2.0-41249083375 | - |
dc.relation.pages | 201-215 | en_US |
dc.relation.journalvolume | 32 | en_US |
dc.relation.journalissue | 2 | en_US |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Institute of Food Safety and Health | - |
crisitem.author.dept | Institute of Environmental and Occupational Health Sciences | - |
crisitem.author.dept | Public Health | - |
crisitem.author.dept | Plant Pathology and Microbiology | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Anatomy and Cell Biology | - |
crisitem.author.dept | Anatomy and Cell Biology | - |
crisitem.author.orcid | 0000-0001-5301-1609 | - |
crisitem.author.orcid | 0000-0001-6264-3608 | - |
crisitem.author.orcid | 0000-0003-0746-0483 | - |
crisitem.author.orcid | 0000-0002-0704-3447 | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 食品安全與健康研究所 |
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