https://scholars.lib.ntu.edu.tw/handle/123456789/604244
標題: | Noninvasive assessment of liver function reserve with fluorescent dosimetry of indocyanine green | 作者: | Wu, Pei Chun Guo, Lun Zhang Yu, Shan Zeng, Ning Liu, Yu Cheng Yu, Jia Zhang, Zhiming Lu, Ke Sun, Liangyu Wang, Chunfei Chang, Yu Han Lu, Yin Lin Shen, Yu Fang Tai, Sheng YUEH-HSUN CHUANG Annie Ho, Ja An KAI-WEN HUANG YAO-MING WU Liu, Tzu Ming |
公開日期: | 1-四月-2022 | 卷: | 13 | 期: | 4 | 來源出版物: | Biomedical Optics Express | 摘要: | Using in vivo multiphoton fluorescent dosimetry, we demonstrate that the clearance dynamics of Indocyanine Green (ICG) in the blood can quickly reveal liver function reserve. In normal rats, the ICG retention rate was below 10% at the 15-minute post-administration; While in the rat with severe hepatocellular carcinoma (HCC), the 15-minute retention rate is over 40% due to poor liver metabolism. With a 785 nm CW laser, the fluorescence dosimeter can evaluate the liver function reserve at a 1/10 clinical dosage of ICG without any blood sampling. In the future, this low-dosage ICG 15-minute retention dosimetry can be applied for the preoperative assessment of hepatectomy or timely perioperative examination. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/604244 | ISSN: | 2156-7085 | DOI: | 10.1364/BOE.446749 |
顯示於: | 醫學系 |
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